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Biomolecules 2012, 2(2), 269-281; doi:10.3390/biom2020269
Article

DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals

1
, 2
, 2
 and 2,*
Received: 3 May 2012; in revised form: 14 May 2012 / Accepted: 16 May 2012 / Published: 24 May 2012
(This article belongs to the Special Issue Protein SUMOylation)
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Abstract: The secretion of insulin by pancreatic islet β-cells plays a pivotal role in glucose homeostasis and diabetes. Recent work suggests an important role for SUMOylation in the control of insulin secretion from β-cells. In this paper we discuss mechanisms whereby (de)SUMOylation may control insulin release by modulating β-cell function at one or more key points; and particularly through the acute and reversible regulation of the exocytotic machinery. Furthermore, we postulate that the SUMO-specific protease SENP1 is an important mediator of insulin exocytosis in response to NADPH, a metabolic secretory signal and major determinant of β-cell redox state. Dialysis of mouse β-cells with NADPH efficiently amplifies β-cell exocytosis even when extracellular glucose is low; an effect that is lost upon knockdown of SENP1. Conversely, over-expression of SENP1 itself augments β-cell exocytosis in a redox-dependent manner. Taken together, we suggest that (de)SUMOylation represents an important mechanism that acutely regulates insulin secretion and that SENP1 can act as an amplifier of insulin exocytosis.
Keywords: insulin; exocytosis; SUMOylation; SENP1; NADPH; redox insulin; exocytosis; SUMOylation; SENP1; NADPH; redox
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Vergari, E.; Plummer, G.; Dai, X.; MacDonald, P.E. DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals. Biomolecules 2012, 2, 269-281.

AMA Style

Vergari E, Plummer G, Dai X, MacDonald PE. DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals. Biomolecules. 2012; 2(2):269-281.

Chicago/Turabian Style

Vergari, Elisa; Plummer, Gregory; Dai, Xiaoqing; MacDonald, Patrick E. 2012. "DeSUMOylation Controls Insulin Exocytosis in Response to Metabolic Signals." Biomolecules 2, no. 2: 269-281.



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