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Metabolites 2015, 5(4), 733-765; doi:10.3390/metabo5040733

Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon

1
Department of Nutrition and Food Sciences, Texas Woman’s University, Denton, TX 76204, USA
2
Department of Medicine, LSU Health Sciences Center, New Orleans, LA 70112, USA
3
Department of Nutrition and Food Sciences, Texas Woman’s University, Houston, TX 77030, USA
4
Department of Medicine, Division of Cardiology, UT Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Meikle
Received: 8 October 2015 / Revised: 2 December 2015 / Accepted: 9 December 2015 / Published: 12 December 2015
(This article belongs to the Special Issue Metabolomic Studies in Metabolic Diseases)
View Full-Text   |   Download PDF [427 KB, uploaded 12 December 2015]   |  

Abstract

There has been an unprecedented worldwide rise in non-communicable metabolic diseases (NCDs), particularly cardiovascular diseases (CVD) and diabetes. While modern pharmacotherapy has decreased the mortality in the existing population, it has failed to stem the rise. Furthermore, a large segment of the world population cannot afford expensive pharmacotherapy. Therefore, there is an urgent need for inexpensive preventive measures to control the rise in CVD and diabetes and associated co-morbidities. The purpose of this review is to explore the role of food bioactives in prevention of NCDs. To this end, we have critically analyzed the possible utility of three classes of food bioactives: (a) resistant starch, a metabolically resistant carbohydrate known to favorably modulate insulin secretion and glucose metabolism; (b) cyclo (His-Pro), a food-derived cyclic dipeptides; and (c) polyphenol-rich berries. Finally, we have also briefly outlined the strategies needed to prepare these food-bioactives for human use. View Full-Text
Keywords: cardiovascular disease; diabetes; food bioactives; functional food; resistant starch; polyphenols; cyclo (His-Pro) cardiovascular disease; diabetes; food bioactives; functional food; resistant starch; polyphenols; cyclo (His-Pro)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Prasad, C.; Imrhan, V.; Juma, S.; Maziarz, M.; Prasad, A.; Tiernan, C.; Vijayagopal, P. Bioactive Plant Metabolites in the Management of Non-Communicable Metabolic Diseases: Looking at Opportunities beyond the Horizon. Metabolites 2015, 5, 733-765.

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