Metabolism at Evolutionary Optimal States
AbstractMetabolism is generally required for cellular maintenance and for the generation of offspring under conditions that support growth. The rates, yields (efficiencies), adaptation time and robustness of metabolism are therefore key determinants of cellular fitness. For biotechnological applications and our understanding of the evolution of metabolism, it is necessary to figure out how the functional system properties of metabolism can be optimized, via adjustments of the kinetics and expression of enzymes, and by rewiring metabolism. The trade-offs that can occur during such optimizations then indicate fundamental limits to evolutionary innovations and bioengineering. In this paper, we review several theoretical and experimental findings about mechanisms for metabolic optimization. View Full-Text
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Rabbers, I.; van Heerden, J.H.; Nordholt, N.; Bachmann, H.; Teusink, B.; Bruggeman, F.J. Metabolism at Evolutionary Optimal States. Metabolites 2015, 5, 311-343.
Rabbers I, van Heerden JH, Nordholt N, Bachmann H, Teusink B, Bruggeman FJ. Metabolism at Evolutionary Optimal States. Metabolites. 2015; 5(2):311-343.Chicago/Turabian Style
Rabbers, Iraes; van Heerden, Johan H.; Nordholt, Niclas; Bachmann, Herwig; Teusink, Bas; Bruggeman, Frank J. 2015. "Metabolism at Evolutionary Optimal States." Metabolites 5, no. 2: 311-343.