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Metabolites 2015, 5(2), 311-343; doi:10.3390/metabo5020311

Metabolism at Evolutionary Optimal States

1
Department of Systems Bioinformatics, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
2
NIZO Food Research, 6718 ZB Ede, The Netherlands
3
Top Institute Food and Nutrition, 6700 AN Wageningen, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Christoph Kaleta
Received: 3 March 2015 / Revised: 20 May 2015 / Accepted: 25 May 2015 / Published: 2 June 2015
(This article belongs to the Special Issue Metabolism and Systems Biology)
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Abstract

Metabolism is generally required for cellular maintenance and for the generation of offspring under conditions that support growth. The rates, yields (efficiencies), adaptation time and robustness of metabolism are therefore key determinants of cellular fitness. For biotechnological applications and our understanding of the evolution of metabolism, it is necessary to figure out how the functional system properties of metabolism can be optimized, via adjustments of the kinetics and expression of enzymes, and by rewiring metabolism. The trade-offs that can occur during such optimizations then indicate fundamental limits to evolutionary innovations and bioengineering. In this paper, we review several theoretical and experimental findings about mechanisms for metabolic optimization. View Full-Text
Keywords: evolution; metabolism; optimality; fitness landscapes; selection pressure; trade-offs evolution; metabolism; optimality; fitness landscapes; selection pressure; trade-offs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Rabbers, I.; van Heerden, J.H.; Nordholt, N.; Bachmann, H.; Teusink, B.; Bruggeman, F.J. Metabolism at Evolutionary Optimal States. Metabolites 2015, 5, 311-343.

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