Next Article in Journal
2-Hydrazinoquinoline as a Derivatization Agent for LC-MS-Based Metabolomic Investigation of Diabetic Ketoacidosis
Previous Article in Journal
Off-the-Vine Ripening of Tomato Fruit Causes Alteration in the Primary Metabolite Composition
Article Menu

Export Article

Open AccessArticle
Metabolites 2013, 3(4), 979-992; doi:10.3390/metabo3040979

Limited Influence of Oxygen on the Evolution of Chemical Diversity in Metabolic Networks

Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, Kawazu 680-4, Iizuka, Fukuoka 820-8502, Japan
*
Author to whom correspondence should be addressed.
Received: 31 July 2013 / Revised: 9 October 2013 / Accepted: 11 October 2013 / Published: 16 October 2013
View Full-Text   |   Download PDF [317 KB, uploaded 16 October 2013]   |  

Abstract

Oxygen is thought to promote species and biomolecule diversity. Previous studies have suggested that oxygen expands metabolic networks by acquiring metabolites with different chemical properties (higher hydrophobicity, for example). However, such conclusions are typically based on biased evaluation, and are therefore non-conclusive. Thus, we re-investigated the effect of oxygen on metabolic evolution using a phylogenetic comparative method and metadata analysis to reduce the bias as much as possible. Notably, we found no difference in metabolic network expansion between aerobes and anaerobes when evaluating phylogenetic relationships. Furthermore, we showed that previous studies have overestimated or underestimated the degrees of differences in the chemical properties (e.g., hydrophobicity) between oxic and anoxic metabolites in metabolic networks of unicellular organisms; however, such overestimation was not observed when considering the metabolic networks of multicellular organisms. These findings indicate that the contribution of oxygen to increased chemical diversity in metabolic networks is lower than previously thought; rather, phylogenetic signals and cell-cell communication result in increased chemical diversity. However, this conclusion does not contradict the effect of oxygen on metabolic evolution; instead, it provides a deeper understanding of how oxygen contributes to metabolic evolution despite several limitations in data analysis methods. View Full-Text
Keywords: metabolism; chemoinformatics; environmental interaction; evolution metabolism; chemoinformatics; environmental interaction; evolution
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Takemoto, K.; Yoshitake, I. Limited Influence of Oxygen on the Evolution of Chemical Diversity in Metabolic Networks. Metabolites 2013, 3, 979-992.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Metabolites EISSN 2218-1989 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top