Next Article in Journal
Scientia Pharmaceutica, Autorenhinweise 2016
Previous Article in Journal
Curcumin-Loaded PLA Nanoparticles: Formulation and Physical Evaluation
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2016, 84(1), 203-217; doi:10.3797/scipharm.ISP.2015.11

In Silico Study to Develop a Lectin-Like Protein from Mushroom Agaricus bisporus for Pharmaceutical Application

1
Dexa Laboratories of Biomolecular Sciences, Industri Selatan V, Blok PP No. 7, Kawasan Industri, Jababeka II, Cikarang 17550, Indonesia.
2
Research group of Pharmaceutics, School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesa 10, Bandung 40132, Indonesia.
3
Research group of Pharmacochemistry, School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesa 10, Bandung 40132, Indonesia.
4
Research group of Biotechnology, School of Pharmacy, Institut Teknologi Bandung, Jl. Ganesa 10, Bandung 40132, Indonesia.
*
Author to whom correspondence should be addressed.
Received: 5 September 2015 / Accepted: 15 December 2015 / Published: 14 February 2016
Download PDF [311 KB, uploaded 7 September 2016]

Abstract

A lectin-like protein of unknown function designated as LSMT was recently discovered in the edible mushroom Agaricus bisporus. The protein shares high structural similarity to HA-33 from Clostridium botulinum (HA33) and Ricin-B-like lectin from the mushroom Clitocybe nebularis (CNL), which have been developed as drug carrier and anti-cancer, respectively. These homologous proteins display the ability to penetrate the intestinal epithelial cell monolayer, and are beneficial for oral administration. As the characteristics of LSMT are unknown, a structural study in silico was performed to assess its potential pharmaceutical application. The study suggested potential binding to target ligands such as HA-33 and CNL although the nature, specificity, capacity, mode, and strength may differ. Further molecular docking experiments suggest that interactions between the LSMT and tested ligands may take place. This finding indicates the possible use of the LSMT protein, initiating new research on its use for pharmaceutical purposes.
Keywords: In silico protein study; Lectin-like protein; Light subunit mushroom tyrosinase; Molecular docking; Novel pharmaceutical protein; Oral delivery In silico protein study; Lectin-like protein; Light subunit mushroom tyrosinase; Molecular docking; Novel pharmaceutical protein; Oral delivery
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

ISMAYA, W.T.; YUNITA; DAMAYANTI, S.; WIJAYA, C.; TJANDRAWINATA, R.R.; RETNONINGRUM, D.S.; RACHMAWATI, H. In Silico Study to Develop a Lectin-Like Protein from Mushroom Agaricus bisporus for Pharmaceutical Application. Sci. Pharm. 2016, 84, 203-217.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top