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Sci. Pharm. 2013, 81(3), 651-662; doi:10.3797/scipharm.1212-21

Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug

1
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No: 71&72, Indrakaran (V), Sangareddy (M), Medak Dist., Hyderabad – 502 329, Andhra Pradesh, India
2
Department of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam – 530 003, Andhra Pradesh, India
*
Author to whom correspondence should be addressed.
Received: 20 December 2012 / Accepted: 18 February 2013 / Published: 18 February 2013
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Abstract

Gatifloxacin is an antibacterial agent belonging to the fourth-generation fluoroquinolone family. Four piperazine-linked fluoroquinolone dimers of Gatifloxacin were observed during the laboratory process for Gatifloxacin and they were identified. The present work describes the origin, synthesis, characterization, and control of these dimers along with the synthesis of Despropylene Gatifloxacin (metabolite).
Keywords: Gatifloxacin; Piperazine dimers; Synthesis; Characterization Gatifloxacin; Piperazine dimers; Synthesis; Characterization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

GARAGA, S.; REDDY, A.V.R.; PRABAHAR, K.J.; KORUPOLU, R.B.; SANASI, P.D. Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug. Sci. Pharm. 2013, 81, 651-662.

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