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Sci. Pharm. 2013, 81(3), 641-650; doi:10.3797/scipharm.1304-17

Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics

Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5–13, 81377 Munich, Germany
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Received: 17 April 2013 / Accepted: 21 August 2013 / Published: 21 August 2013
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Abstract

A novel series of imidazol-5-yl carbinols and their 4-chlorobenzoyl esters has been synthesized by the Grignard reaction and subsequent esterification. These compounds were screened for their antimicrobial activities in an agar diffusion assay. The compounds with C10 to C12-alkyl side chains displayed significant antimycotic activity.
Keywords: Grignard reaction; Ergosterol biosynthesis; Sterol biosynthesis inhibitors; Antimycotics Grignard reaction; Ergosterol biosynthesis; Sterol biosynthesis inhibitors; Antimycotics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

KRAUSS, J.; GRATZL, C.; STURM, V.; MÜLLER, C.; STAUDACHER, V.; SCHMIDT, C.Q.; BRACHER, F. Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics. Sci. Pharm. 2013, 81, 641-650.

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