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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2013, 81(3), 641-650; https://doi.org/10.3797/scipharm.1304-17 (registering DOI)

Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics

Department of Pharmacy – Center for Drug Research, Ludwig-Maximilians University, Butenandtstr. 5–13, 81377 Munich, Germany
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Received: 17 April 2013 / Accepted: 21 August 2013 / Published: 21 August 2013
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Abstract

A novel series of imidazol-5-yl carbinols and their 4-chlorobenzoyl esters has been synthesized by the Grignard reaction and subsequent esterification. These compounds were screened for their antimicrobial activities in an agar diffusion assay. The compounds with C10 to C12-alkyl side chains displayed significant antimycotic activity.
Keywords: Grignard reaction; Ergosterol biosynthesis; Sterol biosynthesis inhibitors; Antimycotics Grignard reaction; Ergosterol biosynthesis; Sterol biosynthesis inhibitors; Antimycotics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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KRAUSS, J.; GRATZL, C.; STURM, V.; MÜLLER, C.; STAUDACHER, V.; SCHMIDT, C.Q.; BRACHER, F. Synthesis and Biological Evaluation of Novel Alkyl-Imidazolyl Carbinols and their Esters: Potent Antimycotics. Sci. Pharm. 2013, 81, 641-650.

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