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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2013, 81(3), 663-676; https://doi.org/10.3797/scipharm.1302-04 (registering DOI)

Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity

Ivan Franko National University of Lviv, Kyryla & Mefodiya Str., 6, 79005 Lviv, Ukraine
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Received: 8 February 2013 / Accepted: 14 April 2013 / Published: 14 April 2013
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Abstract

Anticancer screening of several 1,2,3-triazoles with heterocyclic fragments has been performed. The 1,2,3-triazole derivatives were synthesized from available starting materials according to convenient synthetic procedures. The antitumor activity of the synthesized compounds was tested in vitro by the National Cancer Institute in NCI60 cell lines. It was observed that some compounds showed slight anticancer activity. One of them possessed a moderate activity against melanoma, colon, and breast cancer. Standard COMPARE analysis was performed at the GI50 level.
Keywords: 1,2,3-Triazoles; Pfitzinger reaction; Anticancer activity; COMPARE analysis 1,2,3-Triazoles; Pfitzinger reaction; Anticancer activity; COMPARE analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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POKHODYLO, N.; SHYYKA, O.; MATIYCHUK, V. Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity. Sci. Pharm. 2013, 81, 663-676.

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