Next Article in Journal
How to Solve the Problems of Docking into a Symmetric Binding Site: The Example of the hERG Channel
Previous Article in Journal
Synthesis and Characterization of Potential Dimers of Gatifloxacin – an Antibacterial Drug
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2013, 81(3), 663-676; doi:10.3797/scipharm.1302-04

Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity

Ivan Franko National University of Lviv, Kyryla & Mefodiya Str., 6, 79005 Lviv, Ukraine
*
Author to whom correspondence should be addressed.
Received: 8 February 2013 / Accepted: 14 April 2013 / Published: 14 April 2013
Download PDF [167 KB, uploaded 28 September 2016]

Abstract

Anticancer screening of several 1,2,3-triazoles with heterocyclic fragments has been performed. The 1,2,3-triazole derivatives were synthesized from available starting materials according to convenient synthetic procedures. The antitumor activity of the synthesized compounds was tested in vitro by the National Cancer Institute in NCI60 cell lines. It was observed that some compounds showed slight anticancer activity. One of them possessed a moderate activity against melanoma, colon, and breast cancer. Standard COMPARE analysis was performed at the GI50 level.
Keywords: 1,2,3-Triazoles; Pfitzinger reaction; Anticancer activity; COMPARE analysis 1,2,3-Triazoles; Pfitzinger reaction; Anticancer activity; COMPARE analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

POKHODYLO, N.; SHYYKA, O.; MATIYCHUK, V. Synthesis of 1,2,3-Triazole Derivatives and Evaluation of their Anticancer Activity. Sci. Pharm. 2013, 81, 663-676.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top