Next Article in Journal
Transfersomes: A Novel Vesicular Carrier for Enhanced Transdermal Delivery of Sertraline: Development, Characterization, and Performance Evaluation
Previous Article in Journal
Systematic Development of Self-Emulsifying Drug Delivery Systems of Atorvastatin with Improved Bioavailability Potential
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2012, 80(4), 1045-1060; doi:10.3797/scipharm.1206-09

Formulation and Characterization of Benzoyl Peroxide Gellified Emulsions

MM College of Pharmacy, MM University, Mullana (Ambala) – 133207, India
Department of Biotechnology, Panjab University, Chandigarh – 160014, India
Department of Pharmacy, Government Polytechnic, Uttawar (Faridabad) – 121103, India
Author to whom correspondence should be addressed.
Received: 15 June 2012 / Accepted: 31 August 2012 / Published: 31 August 2012
Download PDF [395 KB, uploaded 30 September 2016]


The present investigation was carried out with the objective of formulating a gellified emulsion of benzoyl peroxide, an anti-acne agent. The formulations were prepared using four different vegetable oils, viz. almond oil, jojoba oil, sesame oil, and wheat germ oil, owing to their emollient properties. The idea was to overcome the skin irritation and dryness caused by benzoyl peroxide, making the formulation more tolerable. The gellified emulsions were characterized for their homogeneity, rheology, spreadability, drug content, and stability. In vitro permeation studies were performed to check the drug permeation through rat skin. The formulations were evaluated for their antimicrobial activity, as well as their acute skin irritation potential. The results were compared with those obtained for the marketed formulation. Later, the histopathological examination of the skin treated with various formulations was carried out. Formulation F3 was found to have caused a very mild dysplastic change to the epidermis. On the other hand, the marketed formulation led to the greatest dysplastic change. Hence, it was concluded that formulation F3, containing sesame oil (6%w/w), was the optimized formulation. It exhibited the maximum drug release and anti-microbial activity, in addition to the least skin irritation potential.
Keywords: Emulgel; Acne vulgaris; Topical drug delivery; Histopathological study Emulgel; Acne vulgaris; Topical drug delivery; Histopathological study
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

THAKUR, N.K.; BHARTI, P.; MAHANT, S.; RAO, R. Formulation and Characterization of Benzoyl Peroxide Gellified Emulsions. Sci. Pharm. 2012, 80, 1045-1060.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics



[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top