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Sci. Pharm. 2012, 80(4), 1027-1044; doi:10.3797/scipharm.1201-06

Systematic Development of Self-Emulsifying Drug Delivery Systems of Atorvastatin with Improved Bioavailability Potential

1
Department of Pharmacy, The University of Asia Pacific, Dhaka-1209, Bangladesh
2
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
3
Department of Pharmacy, State University of Bangladesh, Dhaka-1205, Bangladesh
*
Author to whom correspondence should be addressed.
Received: 8 January 2012 / Accepted: 22 July 2012 / Published: 22 July 2012
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Abstract

The aim of this study was to prepare and characterize a self-emulsifying drug delivery system (SEDDS) with a high drug load of poorly water-soluble atorvastatin for the enhancement of dissolution and oral bioavailability. Solubility of atorvastatin in oil, surfactant, and cosurfactant was determined. Pseudo-ternary phase diagrams were constructed by the aqueous titration method, and formulations were developed based on the optimum excipient combinations. A high drug load (10% w/w) was achieved with a combination of oleic acid, Tween 80, and polyethylene glycol 400, ensuring the maximum dissolution property (in the case of SES6). Effects of lipids and surfactants on physical properties of SEDDS such as in vitro emulsification efficiency in terms of self-emulsification time, emulsion droplet size, and percent transmittance were measured. Multiple regression analysis revealed that a higher amount of surfactants significantly increased dissolution of ATV while decreasing emulsion droplet size and emulsification time. About a four-fold increase in dissolution was achieved by SEDDS compared to pure ATV powder. Overall, this study suggests that dissolution and oral bioavailability of ATV could be improved by SEDDS technology.
Keywords: Self-emulsifying drug delivery systems; Atorvastatin; Oleic acid; Tween 80; Polyethyleneglycol 400 Self-emulsifying drug delivery systems; Atorvastatin; Oleic acid; Tween 80; Polyethyleneglycol 400
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

KHAN, F.; ISLAM, M.S.; RONI, M.A.; JALIL, R.-U. Systematic Development of Self-Emulsifying Drug Delivery Systems of Atorvastatin with Improved Bioavailability Potential. Sci. Pharm. 2012, 80, 1027-1044.

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