Next Article in Journal
Expression of Sulfotransferases and Sulfatases in Human Breast Cancer: Impact on Resveratrol Metabolism
Previous Article in Journal
Absolute Bioavailability and Metabolism of Dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides (“tetraene”) after Intravenous and Oral Single Doses to Rats
Article Menu

Article Versions

Export Article

Open AccessAbstract
Sci. Pharm. 2009, 77(Short Lectures (SL)), 196; doi:10.3797/scipharm.oephg.21.SL-29 (registering DOI)

Expression of Organic Anion Transporter Polypeptides (OATPs) in Human Breast Carcinoma

1
Department of Clinical Pharmacy and Diagnostics, University of Vienna, Althanstraße 14, 1090, Vienna, Austria
2
Center for Physiology and Pathophysiology, Medical University of Vienna, General Hospital Vienna, Waehringerguertel 18-20, 1090, Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Download PDF [197 KB, uploaded 12 May 2017]
Note: In lieu of an abstract, this is an excerpt from the first page.

Excerpt

Organic anion transporter polypeptides (OATPs) mediate the transmembrane uptake of endogenous compounds and clinically important drugs in various tissues thereby effecting drug disposition and tissue penetration. OATPs have also been identified in gastric, pancreatic, and colon carcinomas but little is known about their expression in breast carcinoma. We therefore analyzed the expression pattern of all 11 known OATPs in three breast cancer cell lines (MCF-7, ZR-75-1, MDA-MB-231) and one immortalized breast epithelial cell line (MCF-10A) using quantitative PCR. Transcripts of 7/11 OATP genes with a remarkable heterogeneity in their expression profile were detected in control and/or cancer cell lines.[...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

WLCEK, K.; SVOBODA, M.; THALHAMMER, T.; JÄGER, W. Expression of Organic Anion Transporter Polypeptides (OATPs) in Human Breast Carcinoma. Sci. Pharm. 2009, 77, 196.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top