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Sci. Pharm.
Volume 77
Issue 6
10.3797/scipharm.oephg.21.SL-30
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Abstract

Expression of Sulfotransferases and Sulfatases in Human Breast Cancer: Impact on Resveratrol Metabolism

by
M. MIKSITS
1,*,
K. WLCEK
1,
M. SVOBODA
2,
T. THALHAMMER
2 and
W. JÄGER
1
1
Department of Clinical Pharmacy and Diagnostics, University of Vienna, Althanstraße 14, A-1090, Vienna, Austria
2
Center for Physiology and Pathophysiology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(6), 197; https://doi.org/10.3797/scipharm.oephg.21.SL-30
Submission received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
Versions Notes

Abstract

Resveratrol is a naturally occurring anticancer compound present in grapes and wine that undergoes pronounced metabolism in human intestine and liver. In order to determine whether resveratrol is also biotransformed in human breast carcinoma, metabolism experiments were conducted in breast tumor and adjacent non-tumorous specimens from 13 patients. Resveratrol was metabolized in cytosolic tissue fractions to resveratrol-3-O-sulfate: the formation rates were up to 33.5-fold higher in cancer samples than in peritumoral tissue.

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MDPI and ACS Style

MIKSITS, M.; WLCEK, K.; SVOBODA, M.; THALHAMMER, T.; JÄGER, W. Expression of Sulfotransferases and Sulfatases in Human Breast Cancer: Impact on Resveratrol Metabolism. Sci. Pharm. 2009, 77, 197. https://doi.org/10.3797/scipharm.oephg.21.SL-30

AMA Style

MIKSITS M, WLCEK K, SVOBODA M, THALHAMMER T, JÄGER W. Expression of Sulfotransferases and Sulfatases in Human Breast Cancer: Impact on Resveratrol Metabolism. Scientia Pharmaceutica. 2009; 77(Short Lectures (SL)):197. https://doi.org/10.3797/scipharm.oephg.21.SL-30

Chicago/Turabian Style

MIKSITS, M., K. WLCEK, M. SVOBODA, T. THALHAMMER, and W. JÄGER. 2009. "Expression of Sulfotransferases and Sulfatases in Human Breast Cancer: Impact on Resveratrol Metabolism" Scientia Pharmaceutica 77, Short Lectures (SL): 197. https://doi.org/10.3797/scipharm.oephg.21.SL-30

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