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Sci. Pharm. 2009, 77(Short Lectures (SL)), 195; doi:10.3797/scipharm.oephg.21.SL-28 (registering DOI)

Absolute Bioavailability and Metabolism of Dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides (“tetraene”) after Intravenous and Oral Single Doses to Rats

1
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA
2
Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville, Florida 32610, USA
3
Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens-University Graz, 8010 Graz, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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This study assessed the absolute and relative bioavailabilities of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides (tetraene), one of the main bioactive constituents in Echinacea, administered as pure compounds or as an Echinacea purpurea root extract preparation. Ten rats received 0.75 mg/kg dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides oral, pure and within 158.6 mg/kg Echinacea purpurea extract, or intravenous.[...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

WÖLKART, K.; FRYE, R.; DERENDORF, H.; BAUER, R.; BUTTERWECK, V. Absolute Bioavailability and Metabolism of Dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides (“tetraene”) after Intravenous and Oral Single Doses to Rats. Sci. Pharm. 2009, 77, 195.

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