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Sci. Pharm. 2009, 77(2), 453-464; doi:10.3797/scipharm.0806-08

Preparation and In Vitro Evaluation of a Pegylated Nano-Liposomal Formulation Containing Docetaxel

1
Novel Drug Delivery Systems Lab., Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, PO Box 14155-6451, Iran
2
Research and Development Dept., Sobhan Oncology Company, Rasht, Iran
3
Medical Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, Iran
*
Author to whom correspondence should be addressed.
Received: 9 June 2008 / Accepted: 18 March 2009 / Published: 19 March 2009
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Abstract

An improved pegylated liposomal formulation of docetaxel has been developed with the purpose of improving the docetaxel solubility without any need to use tween80 that is responsible for hypersensitivities following administration. Liposomes all had spherical shape with size of 130–160 nm. The most important finding of this study is that pegylated liposomes were prepared with significant increase in docetaxel encapsulation efficiency and stability of the formulation in comparison with last reports on docetaxel liposomes. In vitro release studies revealed that such a formulation could be stable in the blood circulation and meet the requirements for an effective drug delivery system.
Keywords: Docetaxel; Liposome; Stability; Pegylated; Nanoparticle Docetaxel; Liposome; Stability; Pegylated; Nanoparticle
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

YOUSEFI, A.; ESMAEILI, F.; RAHIMIAN, S.; ATYABI, F.; DINARVAND, R. Preparation and In Vitro Evaluation of a Pegylated Nano-Liposomal Formulation Containing Docetaxel. Sci. Pharm. 2009, 77, 453-464.

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