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Sci. Pharm. 2009, 77(2), 443-452; doi:10.3797/scipharm.0811-24

Development and Characterization of New Indomethacin Self-Nanoemulsifying Formulations

1
Department of Pharmaceutics, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia
2
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Nasr City, Cairo, Egypt
Received: 26 November 2008 / Accepted: 12 March 2009 / Published: 14 March 2009
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Abstract

In the present work a new indomethacin (IND) self-nanoemulsifying drug delivery formulation (SNEDDF) have been prepared to enhance its dissolution which in turn could provide a better chance for IND oral absorption. IND SNEDDF have been prepared using different concentrations of castor oil as a solvent for IND, Cremophor RH 40 (Cr-40) as surfactant and Capmul MCM-C8 (Ca-8) as co-surfactant. Droplets size and turbidity of IND SNEDDFs were measured. Dissolution profile of IND SNEDDFs filled in gelatin capsules was determined by using USP apparatus 2. Ternary phase diagram was constructed to identify the self-nanoemulsifying region after evaluation of IND SNEDDFs by the visual observation. The IND SNEDDFs were thermally characterized using differential scanning calorimetry (DSC) to ensure the compatibility among its ingredients. The present study revealed that the SNEDDFs increased IND dissolution rate and has the potential to enhance its bioavailability without interaction or incompatibility between the ingredients.
Keywords: Indomethacin; Nanoemulsion; DSC; SNEDDF; Dissolution Indomethacin; Nanoemulsion; DSC; SNEDDF; Dissolution
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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TAHA, E.I. Development and Characterization of New Indomethacin Self-Nanoemulsifying Formulations. Sci. Pharm. 2009, 77, 443-452.

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