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Sci. Pharm. 2008, 76(4), 637-652; doi:10.3797/scipharm.0808-13 (registering DOI)

Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical

1
Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Karaj, P.O.Box: 31485-498, Iran
2
Department of Biomedical Physics and Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3
Islamic Azad University, Science and Research Unit, P.O.Box: 14155-775, Tehran, Iran
*
Author to whom correspondence should be addressed.
Received: 19 August 2008 / Accepted: 14 September 2008 / Published: 17 September 2008
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Abstract

[61Cu]-N-(2-hydroxyacetophenone)glycinate ([61Cu]NHAG) was prepared using in house-made NHAG ligand and [61Cu]CuCl2 produced via the natZn(p,x)61Cu (180μA proton irradiation, 22MeV, 3.2h) and purified by a ion chromatography method. [61Cu]NHAG radiochemical purity was >98% and >99.9% by RTLC and HPLC methods respectively after purification by SPE. [61Cu]NHAG was administered into normal and tumor bearing mice followed by biodistribution studies up to 180 minutes. The best tumor accumulation was observed by animal sacrification after 120 min (tumor/muscle and tumor/blood ratios were 25.6 and 3.4 respectively). [61Cu]NHAG is a potential PET radiotracer for tumor imaging.
Keywords: Radiopharmaceuticals; Copper-61; NHAG; Biodistribution; Fibrosarcoma Radiopharmaceuticals; Copper-61; NHAG; Biodistribution; Fibrosarcoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

JALILIAN, A.R.; SADEGHI, H.; ZANDI, H.; ROWSHANFARZAD, P.; SHAFAII, K.; KAMALI-DEHGHAN, M.; GAROUSI, J.; MAJDABADI, A.; TAVAKOLI, M.B. Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical. Sci. Pharm. 2008, 76, 637-652.

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