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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2006, 74(1), 1-19; https://doi.org/10.3797/scipharm.2006.74.1 (registering DOI)

Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines

1
Dept. of Pharm. and Med. Chem. (1 Pharm. Chem. Group, 3 Pharmacol. Group) National Research Center, Dokki, Cairo, Egypt
2
Pharmaceutical Chemistry Dept., Faculty of Pharmacy, Cairo University, Cairo, Egypt
3
Dept. of Pharm. and Med. Chem. (1 Pharm. Chem. Group, 3 Pharmacol. Group) National Research Center, Dokki, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Received: 5 May 2005 / Accepted: 8 November 2005 / Published: 1 March 2006
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Abstract

The synthesis of certain N-aralkyl(1-aminomethylcyclohexyl) benzenamines 6a-i, N-(alkyloxymethyl or aralkyloxymethylcyclohexyl)-N-arylbenzenamines 9a-l and 1-(1-(aralkylphenylamino)cyclohexyl methoxy)-3-isopropylaminopropan-2-ols 11a-c has been accomplished. These compounds exhibited anticonvulsant activity. Compounds 9h, 9b and 11a at doses 0.06, 0.075 and 0.08 mmol/kg, respectively provoked maximal anticonvulsant potential against pentylenetetrazol (PTZ) induced seizures test compared with diphenylhydantoin (0.2 mmol/kg) and valproic acid (0.24mmol/kg).
Keywords: N-aralkyl-N-(1-substitutedcyclohexyl)benzenamines; 1-(1-(aralkylphenyl amino)cyclohexylmethoxy)-3-isopropylaminopropan-2-ol; anticonvulsant activity N-aralkyl-N-(1-substitutedcyclohexyl)benzenamines; 1-(1-(aralkylphenyl amino)cyclohexylmethoxy)-3-isopropylaminopropan-2-ol; anticonvulsant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Aboul-Enein, M.N.; El-Azzouny, A.; Ragab, F.; Soliman, W.; Maklad, Y. Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines. Sci. Pharm. 2006, 74, 1-19.

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