Next Article in Journal
Investigation of the Direct Effects of the Alcoholic Extract of Elaeagnus angustifolia L. (Elaeagnaceae) on Dispersed Intestinal Smooth Muscle Cells of Guinea Pig
Previous Article in Journal
Preparation, Quality Control and Biodistribution Studies of two [111In]-Rituximab Immunoconjugates
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2006, 74(1), 1-19; doi:10.3797/scipharm.2006.74.1 (registering DOI)

Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines

1
Dept. of Pharm. and Med. Chem. (1 Pharm. Chem. Group, 3 Pharmacol. Group) National Research Center, Dokki, Cairo, Egypt
2
Pharmaceutical Chemistry Dept., Faculty of Pharmacy, Cairo University, Cairo, Egypt
3
Dept. of Pharm. and Med. Chem. (1 Pharm. Chem. Group, 3 Pharmacol. Group) National Research Center, Dokki, Cairo, Egypt
*
Author to whom correspondence should be addressed.
Received: 5 May 2005 / Accepted: 8 November 2005 / Published: 1 March 2006
Download PDF [465 KB, uploaded 27 December 2016]

Abstract

The synthesis of certain N-aralkyl(1-aminomethylcyclohexyl) benzenamines 6a-i, N-(alkyloxymethyl or aralkyloxymethylcyclohexyl)-N-arylbenzenamines 9a-l and 1-(1-(aralkylphenylamino)cyclohexyl methoxy)-3-isopropylaminopropan-2-ols 11a-c has been accomplished. These compounds exhibited anticonvulsant activity. Compounds 9h, 9b and 11a at doses 0.06, 0.075 and 0.08 mmol/kg, respectively provoked maximal anticonvulsant potential against pentylenetetrazol (PTZ) induced seizures test compared with diphenylhydantoin (0.2 mmol/kg) and valproic acid (0.24mmol/kg).
Keywords: N-aralkyl-N-(1-substitutedcyclohexyl)benzenamines; 1-(1-(aralkylphenyl amino)cyclohexylmethoxy)-3-isopropylaminopropan-2-ol; anticonvulsant activity N-aralkyl-N-(1-substitutedcyclohexyl)benzenamines; 1-(1-(aralkylphenyl amino)cyclohexylmethoxy)-3-isopropylaminopropan-2-ol; anticonvulsant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Aboul-Enein, M.N.; El-Azzouny, A.; Ragab, F.; Soliman, W.; Maklad, Y. Synthesis and Anticonvulsant Activity of Certain N-Aralkyl-N-(1-Substituted Cyclohexyl) Benzenamines. Sci. Pharm. 2006, 74, 1-19.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top