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Diseases 2014, 2(2), 187-208; doi:10.3390/diseases2020187

Helicobacter pylori: A Brief History of a Still Lacking Vaccine

*  and
Novartis Vaccines, Research Center, Via Fiorentina 1, I-53100 Siena, Italy
* Author to whom correspondence should be addressed.
Received: 16 January 2014 / Revised: 29 April 2014 / Accepted: 19 May 2014 / Published: 16 June 2014
(This article belongs to the Special Issue Helicobacter Pylori Infection)
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Helicobacter pylori colonizes the gastric mucosa of more than half of the human population worldwide. Soon after its discovery, the causative relationships between H. pylori infection and chronic atrophic gastritis, peptic ulcer and gastric mucosa-associated lymphoid tissue lymphoma were evidenced. Then, a significantly increased risk of developing gastric cancer was found to be associated with H. pylori infection. The efficacy of the treatment for H. pylori, based on a proton pump inhibitor plus antibiotics, has dropped below 80%, mainly due to antibiotic resistance. Vaccination would overcome antibiotic resistance and would lead to the eradication of this pathogen; however, in spite of almost twenty-five years of investigation on H. pylori vaccine candidates and good protective results obtained in animal models, no vaccine is currently licensed. This review focuses on the studies on the efficacy of those H. pylori vaccine candidates that underwent clinical trials. Efficacy trials have given unsatisfactory results, so far, with bacterial colonization remaining unaffected by vaccination. However, a vaccine able to counteract H. pylori-induced diseases, such as gastric cancer, even without providing sterilizing immunity, could be considered valuable.
Keywords: Helicobacter pylori; vaccine; animal models; efficacy Helicobacter pylori; vaccine; animal models; efficacy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ruggiero, P.; Censini, S. Helicobacter pylori: A Brief History of a Still Lacking Vaccine. Diseases 2014, 2, 187-208.

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