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Diseases 2013, 1(1), 36-50; doi:10.3390/diseases1010036

The Nervous System Cytoskeleton under Oxidative Stress

* ,
School of Biological Sciences, The University of Sydney, Science Road, Macleay Building A12, Camperdown 2006, Australia
* Author to whom correspondence should be addressed.
Received: 10 September 2013 / Revised: 30 September 2013 / Accepted: 12 October 2013 / Published: 21 October 2013
(This article belongs to the Special Issue Feature Papers)
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Oxidative stress is a key mechanism causing protein aggregation, cell death and neurodegeneration in the nervous system. The neuronal cytoskeleton, that is, microtubules, actin filaments and neurofilaments, plays a key role in defending the nervous system against oxidative stress-induced damage and is also a target for this damage itself. Microtubules appear particularly susceptible to damage, with oxidative stress downregulating key microtubule-associated proteins [MAPs] and affecting tubulin through aberrant post-translational modifications. Actin filaments utilise oxidative stress for their reorganisation and thus may be less susceptible to deleterious effects. However, because cytoskeletal components are interconnected through crosslinking proteins, damage to one component affects the entire cytoskeletal network. Neurofilaments are phosphorylated under oxidative stress, leading to the formation of protein aggregates reminiscent of those seen in neurodegenerative diseases. Drugs that target the cytoskeleton may thus be of great use in treating various neurodegenerative diseases caused by oxidative stress.
Keywords: microtubule; actin; neurofilament; posttranslational modification microtubule; actin; neurofilament; posttranslational modification
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Gardiner, J.; Overall, R.; Marc, J. The Nervous System Cytoskeleton under Oxidative Stress. Diseases 2013, 1, 36-50.

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