The Complex Nature of Adherence in the Management of HIV/AIDS as a Chronic Medical Condition
Abstract
:1. Introduction
6. Strategies and Tools for Enhancing Adherence
6.2. Education and Counselling
6.3. Adherence Tools for Patients
6.5. Health System and Service Delivery Interventions
7. Conclusion
Conflicts of Interest
References
- Sanjobo, N.; Frich, J.C.; Fretheim, A. Barriers and facilitators to patients’ adherence to antiretroviral treatment in Zambia: a qualitative study. J. Soc. Asp. H 2008, 5, 136–143. [Google Scholar]
- Kenreigh, C.A.; Wagner, L.T. Medication adherence: A literature review. Medscape 2005.
- Cauldbeck, M.; O’Connor, C.; O’Connor, M.; Saunders, J.; Rao, B.; Mallesh, V.; Kotechalappa, N.; Kumar, P.; Mamtha, G.; McGoldrick, C.; Laing, R.; Satish, S. Adherence to antiretroviral therapy among HIV patients in Bangalore, India. AIDS Res. Ther. 2009, 6, 7. [Google Scholar] [CrossRef]
- Ickovics, J.R.; Meade, C.S. Adherence to antiretroviral therapy among patients with HIV: A critical link between behavioural and biomedical sciences. J. Acq. Immun. Def. Synd. 2002, 31, S98–S102. [Google Scholar] [CrossRef]
- McDonald, H.P.; Garg, A.X.; Haynes, R.B. Interventions to enhance patient adherence to medication prescriptions. JAMA 2002, 288, 2868–2879. [Google Scholar] [CrossRef]
- Van Dulmen, S.; Sluijs, E.; van Dijk, L.; de Riddet, D.; Heerdink, R.; Bensing, J. Patient adherence to medical treatment: a review of reviews. BMC Health Serv. Res. 2007, 7, 55. [Google Scholar] [CrossRef]
- Mills, E.J.; Nachega, J.B.; Buchan, I.; Orbinski, J.; Attaran, A.; Singh, S.; Rachlis, B.; Wu, P.; Cooper, C.; Thabane, L.; et al. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: A meta-analysis. JAMA 2006, 296, 679–690. [Google Scholar] [CrossRef]
- Chesney, M.A. Factors affecting adherence to antiretroviral therapy. Clin. Infect. Dis. 2000, 30, S171–S176. [Google Scholar] [CrossRef]
- Protopopescu, C.; Raffi, F.; Roux, P.; Reynes, J.; Dellamonica, P.; Spire, B.; Leport, C.; Carrieri, M.; and on behalf of the ANRS CO8 (APROCO-COPILOTE) Study Group. Factors associated with non-adherence to long-term highly active antiretroviral therapy: a 10-year follow-up analysis with correction for the bias induced by missing data. J. Antimicrob. Chemoth. 2009, 64, 599–606. [Google Scholar] [CrossRef]
- Murphy, D.A.; Sarr, M.; Durako, S.J.; Moscicki, A.; Wilson, C.M.; Muenz, L.R.; for the Adolescent Medicine HIV/AIDS Research Network. Barriers to HAART adherence among HIV-infected adolescents. Arch. Pediatr. Adolesc. Med. 2003, 157, 249–255. [Google Scholar] [CrossRef]
- Nachega, J.; Hislop, M.; Nguyen, H.; Dowdy, D.; Regensberg, L.; Chaisson, R.; Cotton, M.; Maartens, G. Antiretroviral therapy adherence, Virologic and immunologic outcomes in adolescents compared with adults in Southern Africa. J. Acq. Immun. Def. Synd. 2009, 51, 65–71. [Google Scholar] [CrossRef]
- Amico, K.R.; Harman, J.J.; Johnson, B.T. Efficacy of antiretroviral therapy adherence interventions a research synthesis of trials, 1996 to 2004. J. Acq. Immun. Def. Synd. 2006, 41, 285–297. [Google Scholar] [CrossRef]
- Munro, S.; Lewin, S.; Swart, T.; Volmink, J. A review of health behaviour theories: how useful are these for developing interventions to promote long-term medication adherence for TB and HIV/AIDS. BMC Public Health 2007, 7, 104. [Google Scholar] [CrossRef]
- Simoni, J.M.; Frick, P.A.; Pantalone, D.W.; Turner, B.J. Antiretroviral adherence interventions: A review of current literature and ongoing studies. Top. HIV Med. 2003, 11, 185–198. [Google Scholar]
- Kagee, A. Adherence to antiretroviral therapy in the context of the national roll-out in South Africa: Defining a research agenda for psychology. S Afr. J. Psychol. 2008, 38, 413–428. [Google Scholar]
- Paterson, D.L.; Swindells, S.; Mohr, J.; Brester, M.; Vergis, E.N.; Squier, C.; Wagener, M.M.; Singh, N. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann. Intern. Med. 2000, 133, 21–30. [Google Scholar]
- Bangsberg, D.R.; Moss, A.R.; Deeks, S.G. Paradoxes of adherence and drug resistance to HIV antiretroviral therapy. J. Antimicrob. Chemoth. 2004, 53, 696–699. [Google Scholar] [CrossRef]
- Clotet, B. Strategies for overcoming resistance in HIV-1 infected patients receiving HAART. AIDS Reviews 2004, 6, 123–130. [Google Scholar]
- Gazzard, B.G; on behalf of the BHIVA Treatment Guidelines Writing Group. British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008. HIV Medicine 2008, 9, 563–608. [Google Scholar] [CrossRef]
- Thompson, M.; Aberg, J.; Cahn, P.; Montaner, J.; Rizzardini, G.; Telenti, A.; Gatell, J.M.; Günthard, H.; Hammer, S.; Hirsch, M.; et al. Antiretroviral treatment of adult HIV infection: 2010 Recommendations of the International AIDS Society—USA Panel. JAMA 2010, 304, 321–333. [Google Scholar] [CrossRef]
- Nachega, J.B.; Hislop, M.; Dowdy, D.W.; Chaisson, R.E.; Regensberg, L.; Maartens, G. Adherence to non-nucleoside reverse transcriptase inhibitor-based HIV therapy and virologic outcomes. Ann. Intern. Med. 2007, 146, 564–573. [Google Scholar] [CrossRef]
- Bangsberg, D.R. Less than 95% adherence to nucleoside reverse transcriptase inhibitors therapy can lead to viral suppression. Clin. Infect. Dis. 2006, 43, 939–941. [Google Scholar] [CrossRef]
- Weiser, S.; Wolfe, W.; Bangsberg, D.; Thior, I.; Gilbert, P.; Makhema, J.; Kebaabetswe, P.; Dickenson, D.; Mompati, K.; Essex, M.; et al. Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana. J. Acq. Immun. Def. Synd. 2003, 34, 281–288. [Google Scholar] [CrossRef]
- Amberbir, A.; Woldemichael, K.; Getachew, S.; Girma, B.; Deribe, K. Predictors of adherence to antiretroviral therapy among HIV-infected persons: a prospective study in southwest Ethiopia. BMC Public Health 2008, 8, 268. [Google Scholar] [CrossRef]
- Uzochukwu, B.S.C.; Onwujekwe, O.E.; Onoka, A.C.; Okoli, C.; Uguru, N.P.; Chukwuogo, O.I. Determinants of non-adherence to subsidized antiretroviral treatment in southeast Nigeria. Health Policy Plan. 2009, 24, 189–196. [Google Scholar] [CrossRef]
- Peltzer, K.; du Preez, N.; Ramlagan, S.; Anderson, J. Antiretroviral treatment adherence among HIV patients in KwaZulu-Natal, South Africa. BMC Public Health 2010, 10, 111. [Google Scholar] [CrossRef]
- Malangu, N.G. Self-reported adverse effects as barriers to adherence to antiretroviral therapy in HIV-infected patients in Pretoria. SA Fam. Pract. 2008, 50, 49. [Google Scholar]
- Janssens, B.; Raleigh, B.; Soeung, S.; Akao, K.; Te, V.; Gupta, J.; Chhy Vun, M.; Ford, N.; Nouhin, J.; Nerrienet, E. Effectiveness of highly active antiretroviral therapy in HIV-positive children: Evaluation at 12 Months in a routine program in Cambodia. Pediatrics 2007, 120, e1134–e1140. [Google Scholar] [CrossRef] [Green Version]
- Duong, M.; Golzi, A.; Peytavin, G.; Piroth, L.; Froidure, M.; Grappin, M.; Buisson, M.; Kohli, E.; Chavanet, P.; Portier, H. Usefulness of therapeutic drug monitoring of antiretroviral in routine clinical practice. HIV Clin. Trials 2004, 5, 216–223. [Google Scholar] [CrossRef]
- Ware, N.C.; Idoko, J.; Kaaya, S.; Biraro, I.A.; Wyatt, M.A.; Agbaji, O.; Chalamilla, G.; Bangsberg, D.R. Explaining adherence success in sub-Saharan Africa: an ethnographic study. PLOS Med. 2009, 6, e1000011. [Google Scholar]
- Bangsberg, D.R.; Charlebois, E.D.; Grant, R.M.; Holodniy, M.; Deeks, S.G.; Perry, S.; Conroy, K.N.; Clark, R.; Guzman, D.; Zolopa, A.; et al. High levels of adherence do not prevent accumulation of drug resistance mutations. AIDS 2003, 17, 1925–1932. [Google Scholar] [CrossRef]
- Nachega, J.B.; Hislop, M.; Dowdy, D.W.; Lo, M.; Omer, S.B.; Regensberg, L.; Chaisson, R.E.; Maartens, G. Adherence to highly active antiretroviral therapy assessed by pharmacy claims predicts survival in HIV-infected South African adults. J. Acq. Immun. Def. Synd. 2006, 43, 78–84. [Google Scholar] [CrossRef]
- Rubbert, A.; Behrens, G.; Ostrowski, M. Ch 4—Pathogenesis of HIV-1 infection. In HIV Medicine; Hoffman, C., Rockstroh, J., Kamps, B., Eds.; Flying Publisher: Paris, France, 2007; pp. 59–81. [Google Scholar]
- Graham, S.M.; Masese, L.; Gitau, R.; Jalalian-Lechak, Z.; Richardson, B.A.; Peshu, N.; Mandaliya, K.; Kiarie, J.N.; Jaoko, W.; Ndinya-Achola, J.; et al. Antiretroviral adherence and development of drug resistance are the strongest predictors of genital HIV-1 shedding among women initiating treatment. J. Infect. Dis. 2010, 201, 1538–1542. [Google Scholar]
- Moore, D.M.; Hogg, R.S.; Yip, B.; Wood, E.; Tyndall, M.; Braitstein, P.; Montaner, J.S. Discordant immunologic and virologic responses to highly active antiretroviral therapy are associated with increased mortality and poor adherence to therapy. J. Acq. Immun. Def. Synd. 2005, 40, 288–293. [Google Scholar] [CrossRef]
- Wools-Kaloustian, K.; Kimayo, S.; Diero, L.; Siika, A.; Sidle, J.; Yiannoustsos, T.; Musick, B.; Einterz, R.; Fife, K.; Tierney, W. Viability and effectiveness of large-scale HIV treatment initiatives in Sub-Saharan Africa: experience from western Kenya. AIDS 2006, 20, 41–48. [Google Scholar] [CrossRef]
- Boyd, M.; Pett, S. HIV fusion inhibitors: a review. Aust. Prescr. 2008, 31, 66–69. [Google Scholar]
- Hogg, R.S.; Heath, K.; Bangsberg, D.; Yip, B.; Press, N.; O'Shaughnessy, M.V.; Montaner, J.S. Intermittent use of triple-combination therapy is predictive of mortality at baseline and after 1 year of follow-up. AIDS 2002, 16, 1051–1058. [Google Scholar] [CrossRef]
- de Olalla, P.G.; Knobel, H.; Carmona, A.; Guelar, A.; Lopez-Colomes, J.L.; Cayla, J.A. Impact of adherence and highly active antiretroviral therapy on survival in HIV-infected patients. J. Acq. Immun. Def. Synd. 2002, 30, 105–110. [Google Scholar]
- Dahab, M.; Charalambous, S.; Hamilton, R.; Fielding, K.; Kielmann, K.; Churchyard, G.J.; Grant, A.D. “That is why I stopped the ART”: patients’ and providers’ perspectives on barrier to and enablers of HIV treatment adherence in a South African workplace programme. BMC Public Health 2008, 8, 63. [Google Scholar] [CrossRef]
- Curioso, W.H.; Kepka, D.; Cabello, R.; Segura, P.; Kurth, A.E. Understanding the facilitators and barriers of antiretroviral adherence in Peru: a qualitative study. BMC Public Health 2010, 10, 13. [Google Scholar] [CrossRef]
- San Lio, M.M.; Carbini, R.; Germano, P.; Guidotti, G.; Mancinelli, S.; Magid, N.A.; Narciso, P.; Palombi, L.; Renzi, E.; Zimba, I.; et al. Evaluation of adherence to highly active antiretroviral therapy with use of pills counts and viral load measurement in the drug resources enhancement against AIDS and malnutrition program in Mozambique. Clin. Infect. Dis. 2008, 46, 1609–1616. [Google Scholar] [CrossRef] [Green Version]
- Hardon, A.P.; Akurut, D.; Comoro, C.; Ekezie, C.; Irunde, H.F.; Gerrits, T.; Kglatwane, J.; Kinsman, J.; Kwasa, R.; Maridadi, J.; et al. Hunger, Waiting time and transport costs: Time to confront challenges to ART adherence in Africa. AIDS Care 2007, 19, 658–665. [Google Scholar] [CrossRef]
- Oyugi, J.H.; Byakika-Tusiime, J.; Charlebois, E.D.; Kityo, C.; Mugerwa, R.; Mugyenyi, P.; Bangsberg, D.R. Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting. J. Acq. Immun. Def. Synd. 2004, 36, 1100–1102. [Google Scholar] [CrossRef]
- Fox, M.P.; Rosen, S. Patient retention in antiretroviral therapy programs up to three years on treatment in sub-Saharan Africa, 2007–2009: Systematic review. Trop. Med. Int. Health 2010, 15, 1–15. [Google Scholar]
- Montessori, V.; Press, N.; Harris, M.; Akagi, L.; Montaner, J. Adverse effects of antiretroviral therapy for HIV infection. Can. Med. Assoc. J. 2004, 170, 229–238. [Google Scholar]
- Orrell, C.; Bangsberg, D.R.; Badri, M.; Wood, R. Adherence is not a barrier to successful antiretroviral therapy in South Africa. AIDS 2003, 17, 1369–1375. [Google Scholar] [CrossRef]
- Rougemont, M.; Stoll, B.; Elia, N.; Ngang, P. Antiretroviral treatment adherence and its determinants in Sub-Saharan Africa: A prospective study at Yaoundé central hospital, Cameroon. AIDS Res. Ther. 2009, 6, 21. [Google Scholar] [CrossRef]
- Gordillo, V.; del Amo, J.; Soriano, V.; Gonzalez-Lahoz, J. Socio-demographic and psychological variables influencing adherence to antiretroviral therapy. AIDS 1999, 13, 1763–1769. [Google Scholar] [CrossRef]
- Berg, K.M.; Cooperman, N.A.; Newville, H.; Arnsten, J.H. Self-efficacy and depression as mediators of the relationship between pain and antiretroviral adherence. AIDS Care 2009, 21, 244–248. [Google Scholar] [CrossRef]
- Howard, A.A.; Armsten, J.H.; Yuntai, L.; Vlahov, D.; Rich, J.D.; Schumand, P.; Stonee, V.E.; Smith, D.K.; Schoenbaum, E.E.; for HER study group. A prospective study of adherence and viral load in a large multi-centre cohort of HIV-infected women. AIDS 2002, 16, 2175–2182. [Google Scholar] [CrossRef]
- Glass, T.R.; Battegay, M.; Cavassini, M.; De Geest, S.; Furrer, H.; Vernazza, P.L.; Hirschel, B.; Bernasconi, E.; Rickenbach, M.; Günthard, H.F.; Bucher, H.C.; The Swiss HIV cohort study. Longitudinal analysis of patterns and predictors of changes in self-reported adherence to antiretroviral therapy: Swiss HIV Cohort Study. J. Acq. Immun. Def. Synd. 2010, 54, 197–203. [Google Scholar]
- Hawkins, C.; Murphy, R. Adherence to antiretroviral therapy in resource-limited settings: everything matters. AIDS 2007, 21, 1041–1042. [Google Scholar] [CrossRef]
- Iliyasu, Z.; Kabir, M.; Abubakar, I.S.; Babashani, M.; Zubair, Z.A. Compliance to antiretroviral therapy among AIDS patients in Aminu Kano Teaching Hospital, Kano, Nigeria. Niger J. Med. 2005, 14, 290–294. [Google Scholar]
- Mukhtar-Yola, M.; Adeleke, S.; Gwarzo, D.; Ladan, Z. Preliminary investigation of adherence to antiretroviral therapy among children in Aminu Kano Teaching Hospital, Nigeria. AJAR 2006, 5, 141–144. [Google Scholar] [CrossRef]
- Tuller, D.M.; Bangsberg, D.R.; Senkungu, J.; Ware, N.C.; Emenyonu, N.; Weiser, S.D. Transportation costs impede sustained adherence and access to HAART in a clinic population in Southwestern Uganda. AIDS Behav. 2009, 14, 778–784. [Google Scholar]
- Castro, A. Adherence to antiretroviral therapy: merging the clinical and social course of AIDS. PLoS Med. 2005, 2, e338. [Google Scholar] [CrossRef]
- Nachega, J.B.; Stein, D.M.; Lehman, D.A.; Hlatshwayo, D.; Mothopeng, R.; Chaisson, R.E.; Karstaedt, A.S. Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. AIDS Res. Hum. Retroviruses 2004, 20, 1053–1056. [Google Scholar] [CrossRef]
- Garcia, R.; Badaro, R.; Netto, E.; Silva, M.; Amorin, F.; Ramos, A.; Vaida, F.; Brites, C.; Schooley, R. Cross-sectional study to evaluate factors associated with adherence to antiretroviral therapy by Brazilian HIV-infected patients. AIDS Res. Hum. Retroviruses 2006, 22, 1248–1252. [Google Scholar] [CrossRef]
- Mukherjee, J.S.; Ivers, L.; Leandre, F.; Farmer, P.; Behforouz, H. Antiretroviral therapy in resource-poor settings: Decreasing barriers to access and promoting adherence. J. Acq. Immun. Def. Synd. 2006, 43, S123–S126. [Google Scholar] [CrossRef]
- Frank, I. Once-daily HAART: toward a new treatment paradigm. J. Acq. Immun. Def. Synd. 2002, 31, S10–S15. [Google Scholar] [CrossRef]
- Roca, B.; Lapuebula, C.; Vidal-Tregedor, B. HAART with didanosine once versus twice daily: adherence and efficacy. Int. J. Infect. Dis. 2005, 9, 195–200. [Google Scholar] [CrossRef]
- Waters, L.; Nelson, M. Why do patients fail HIV therapy? Int. J. Clin. Pract. 2007, 61, 983–990. [Google Scholar] [CrossRef]
- Harries, A.D.; Zachariah, R.; Lawn, S.D.; Rosen, S. Strategies to improve patient retention on antiretroviral therapy in sub-Saharan Africa. Trop. Med. Int. Health 2010, 15, 70–75. [Google Scholar] [CrossRef] [Green Version]
- Parienti, J.J.; Bangsberg, D.R.; Verdon, R.; Gardner, E.M. Better adherence with once-daily antiretroviral regimens: A meta-analysis. Clin. Infect. Dis. 2009, 48, 484–488. [Google Scholar] [CrossRef]
- Gauchet, A.; Tarquinio, C.; Fischer, G. Psychosocial predictors of medication adherence among persons living with HIV. Int. J. Behav. Med. 2007, 3, 141–150. [Google Scholar] [CrossRef]
- Altice, F.L.; Mostashari, F.; Friedland, G.H. Trust and acceptance of and adherence to antiretroviral therapy. J. Acq. Immun. Def. Synd. 2001, 28, 47–58. [Google Scholar]
- Simoni, J.M.; Pearson, C.R.; Pantalone, D.W.; Marks, G.; Crepaz, N. Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load: A meta-analytic review of randomized controlled trials. J. Acq. Immun. Def. Synd. 2006, 43, S23–S35. [Google Scholar] [CrossRef]
- Julius, R.J.; Novitsky, M.A.; Dubin, W.R. Medication adherence: a review of the literature and implications for clinical practice. J. Psychiatr. Pract. 2009, 15, 34–44. [Google Scholar] [CrossRef]
- Colebunders, R.; Moses, K.R.; Laurence, J.; Shihab, H.M.; Semitala, F.; Lutwama, F.; Bakeera-Kitaka, S.; Lynen, L.; Spacek, L.; Reynolds, S.J.; et al. A new model to monitor the virological efficacy of antiretroviral treatment in resource poor countries. Lancet Infect. Dis. 2006, 6, 53–59. [Google Scholar] [CrossRef]
- Kouanfack, C.; Laurent, C.; Peytavin, G.; Ciaffi, L.; Ngolle, M.; Nkene, Y.M.; Essomba, C.; Calmy, A.; Mpoudi-Ngole, E.; Delaporte, E.; et al.; the French national agency for research on AIDS 1274 study group Adherence to antiretroviral therapy assessed by drug level monitoring and self-reports in Cameroon. J. Acq. Immun. Def. Synd. 2008, 48, 216–219. [Google Scholar] [CrossRef]
- Ross-Degnan, D.; Pierre-Jacques, M.; Zhang, F.; Tadeg, H.; Gitau, L.; Ntaganira, J.; Balikuddembe, R.; Chalker, J.; Wagner, A.K.; INRUD IAA7. Measuring adherence to antiretroviral treatment in resource poor settings: the clinical validity of key indicators. BMC Health Serv. Res. 2010, 10, 42. [Google Scholar] [CrossRef]
- Bell, D.J.; Kapitao, Y.; Sikwese, R.; van Oosterhout, J.J.; Lallo, D.G. Adherence to antiretroviral therapy in patients receiving free treatment from a government hospital in Blantyre, Malawi. J. Acq. Immun. Def. Synd. 2007, 45, 560–563. [Google Scholar] [CrossRef]
- Bova, C.A.; Fennie, K.P.; Knafi, G.J.; Dieckhaus, K.D.; Watrous, E.; Williams, A.B. Use of electronic monitoring devices to measure antiretroviral adherence: practical considerations. AIDS Behav. 2005, 9, 103–110. [Google Scholar] [CrossRef]
- Wilson, D.; Keiluhu, A.K.; Kogrum, S.; Reid, T.; Seriratana, N.; Ford, N.; Kyawkyaw, M.; Talangsri, P.; Taochalee, N. HIV-1 viral load monitoring: an opportunity to reinforce treatment adherence in a resource-limited setting in Thailand. T Roy. Soc. Trop. Med. H 2009, 103, 601–606. [Google Scholar] [CrossRef] [Green Version]
- Birbeck , G.L.; Chomba, E.; Kvalsund, M.; Bradbury, R.; Mang’ombe, M.; Malama, K.; Kail, T.; Byers, P.A.; Organek, N.; for the RAAZ Study Team. Antiretroviral adherence in rural Zambia: The first year of treatment availability. Am. J. Trop. Med. Hyg. 2009, 80, 669–674. [Google Scholar]
- Kauf, T.L.; Davis, K.L.; Earnshaw, S.R.; Davis, E.A. Spillover adherence effects of fixed-dose combination HIV therapy. Patient Prefer. Adherence 2012, 6, 155–164. [Google Scholar]
- Haberer, J.E.; Cook, A.; Walker, A.S.; Ngambi, M.; Ferrier, A.; Mulenga, V.; Kityo, C.; Thomason, M.; Kabamba, D.; Chintu, C.; et al. Excellent adherence to antiretroviral in HIV+ Zambian children is compromised by disrupted routine, HIV nondisclosure, and paradoxical income effects. PLoS ONE 2011, 6, e18505. [Google Scholar] [CrossRef]
- Nachega, J.B.; Knowlton, A.R.; Deluca, A.; Schoeman, J.H.; Watkinson, L.; Efron, A.; Chaisson, R.E.; Maartens, G. Treatment supporter to improve adherence to antiretroviral therapy in HIV-infected South African adults: a qualitative study. J. Acq. Immun. Def. 2006, 43, S127–S133. [Google Scholar] [CrossRef]
- Magadza, C.; Radloff, S.E.; Srinivas, S.C. The effect of an educational intervention on patients’ knowledge about hypertension, beliefs about medicines, and adherence. Res. Social Adm. Pharm. 2009, 5, 363–375. [Google Scholar] [CrossRef]
- Barclay, T.R.; Hinkin, C.H.; Castellon, S.A.; Mason, K.I.; Reinhard, M.J.; Marion, S.D.; Levine, A.J.; Durvasula, R.S. Age-associated predictors of medication adherence in HIV-positive adults: health beliefs, self-efficacy and neurocognitive status. Health Psychol. 2007, 26, 40–49. [Google Scholar] [CrossRef]
- Johnson, M.O.; Charlebois, E.; Morin, S.F.; Remien, R.H.; Chesney, M.A.; The NIMH Healthy Living Project Team. Effects of a behavioural intervention on antiretroviral medication adherence among people living with HIV: The Healthy Living Project randomized controlled study. J. Acq. Immun. Def. Synd. 2007, 46, 574–580. [Google Scholar] [CrossRef]
- Mannheimer, S.B.; Morse, E.; Matts, J.P.; Andrews, L.; Child, C.; Schmetter, B.; Friedland, G.H.; (For the Terry Beirn community programs for clinical research on AIDS). Sustained benefit from a long-term antiretroviral adherence intervention: Results of a large randomized clinical trial. J. Acq. Immun. Def. Synd. 2006, 43, S41–S47. [Google Scholar] [CrossRef]
- Saberi, P.; Johnson, M.O. Technology-based self-care methods of improving antiretroviral adherence: A systematic review. PLoS ONE 2011, 6, e27533. [Google Scholar] [CrossRef]
- Bärnighausen, T.; Chaiyachati, K.; Chimbindi, N.; Peoples, A.; Haberer, J.; Newell, M.L. Interventions to increase antiretroviral adherence in sub-Saharan Africa: a systematic review of evaluation studies. Lancet Infect. Dis. 2011, 11, 942–951. [Google Scholar] [CrossRef]
- Van Velthoven, M.H.; Brusamento, S.; Majeed, A.; Car, J. Scope and effectiveness of mobile phone messaging for HIV/AIDS care: a systematic review. Psychol. Health Med. 2013, 18, 182–202. [Google Scholar] [CrossRef]
- Rodrigues, R.; Shet, A.; Antony, J.; Sidney, K.; Arumugam, K.; Krishnamurthy, S.; D’Souza, G.; DeCosta, A. Supporting Adherence to Antiretroviral Therapy with Mobile Phone Reminders: Results from a Cohort in South India. PLoS ONE 2012, 7, e40723. [Google Scholar] [CrossRef]
- Skinner, D.; Rivette, U.; Bloomberg, D. Evaluation of use of cellphones to aid compliance with drug therapy for HIV patients. AIDS Care 2007, 19, 605–607. [Google Scholar] [CrossRef]
- Clarke, M.; Dick, J.; Zwarenstein, M.; Lombard, C.J.; Diwan, V.K. Lay health worker intervention with choice of DOT superior to standard TB care for farm dwellers in South Africa: a cluster randomized control trial. Int. J. Tuber. Lung Dis. 2005, 9, 673–679. [Google Scholar]
- Manders, A.J.; Banerjee, A.; van den Borne, H.W.; Harries, A.D.; Kok, G.J.; Salaniponi, F.M. Can guardians supervise TB treatment as well as health workers? A study on adherence during the intensive phase. Int. J. Tuber. Lung Dis. 2001, 9, 838–842. [Google Scholar]
- Wilkinson, D.; Davies, G.R.; Connolly, C. Directly observed therapy for tuberculosis in rural South Africa, 1991 through 1994. Am. J. Public Health 1996, 86, 1094–1097. [Google Scholar] [CrossRef]
- Farmer, P.; Leandre, F.; Mukherjee, J.; Gupta, R.; Tarter, L.; Kim, J.Y. Community-based treatment of advance HIV disease: Introducing DOT-HAART (directly observed therapy with highly active antiretroviral therapy). Bull. World Health Organ. 2001, 79, 1145–1151. [Google Scholar]
- Lucas, G.M.; Flexner, C.W.; Moore, R.D. Directly administered antiretroviral therapy in the treatment of HIV infection: benefit or burden? AIDS Patient Care STDS 2002, 16, 527–535. [Google Scholar] [CrossRef]
- Sarna, A.; Lutchers, S.; Giebel, S.; Chersich, M.F.; Munyao, P.; Kaai, S.; Mandaliya, K.N.; Shikely, K.S.; Temmerman, M.; Rutenberg, N. Short and long term efficacy of modified directly observed antiretroviral treatment Mombasa, Kenya: a randomized trial. J. Acq. Immun. Def. Synd. 2008, 48, 611–619. [Google Scholar] [CrossRef]
- Serrano, C.; Laporte, R.; Ide, M.; Nouhou, Y.; Truchis, P.; Rouveix, E.; Adamou, A.; Pauly, V.; Mattei, J.F.; Gastaut, J.A. Family nutritional support improves survival, immune restoration and adherence in HIV patients receiving ART in developing country. Asia Pac. J. Clin. Nutr. 2010, 19, 68–75. [Google Scholar]
- Sanne, I.; Orrell, C.; Fox, M.P.; Conradie, F.; Ive, P.; Zeinecker, J.; Cornell, M.; Heiberg, C.; Ingram, C.; Panchia, R.; et al.; for CIPRA-SA Study Team Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): a randomized non-inferiority trial. Lancet 2010, 376, 33–40. [Google Scholar] [CrossRef]
- Andersen, M.; Hockman, E.; Smereck, G.; Tinsley, J.; Milfort, D.; Wilcox, R.; Smith, T.; Connelly, C.; Adams, L.; Thomas, R. Retaining women in HIV medical care. J. Assoc. Nurse AIDS C 2007, 18, 33–41. [Google Scholar] [CrossRef]
- Volberding, P.A.; Deeks, S.G. Antiretroviral therapy and management of HIV infection. Lancet 2010, 376, 49–62. [Google Scholar] [CrossRef]
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Adefolalu, A.O.; Nkosi, Z.Z. The Complex Nature of Adherence in the Management of HIV/AIDS as a Chronic Medical Condition. Diseases 2013, 1, 18-35. https://doi.org/10.3390/diseases1010018
Adefolalu AO, Nkosi ZZ. The Complex Nature of Adherence in the Management of HIV/AIDS as a Chronic Medical Condition. Diseases. 2013; 1(1):18-35. https://doi.org/10.3390/diseases1010018
Chicago/Turabian StyleAdefolalu, Adegoke O., and Zerish Z. Nkosi. 2013. "The Complex Nature of Adherence in the Management of HIV/AIDS as a Chronic Medical Condition" Diseases 1, no. 1: 18-35. https://doi.org/10.3390/diseases1010018