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Cosmetics 2017, 4(2), 18; doi:10.3390/cosmetics4020018

Anti-Skin-Aging Activity of a Standardized Extract from Panax ginseng Leaves In Vitro and In Human Volunteer

Biospectrum Life Science Institute, U-TOWER 18th FL, 767, Sinsu Ro, Suji Gu, Yongin City, Gyunggi Do 16827, Korea
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Author to whom correspondence should be addressed.
Academic Editor: Enzo Berardesca
Received: 11 April 2017 / Revised: 24 May 2017 / Accepted: 25 May 2017 / Published: 1 June 2017
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Abstract

Ginseng leaves contain high saponin composition and content, but are used less often than the root part. To develop a use for the leaves that exploits their properties, we studied ginseng leaves as the raw material of anti-aging cosmetics. This study highlights an assessment of the cellular factivity and clinical efficacy of ginseng leaf extract, providing necessary information relevant to the development of new cosmetic products. Panax ginseng leaf purified extracts (PGLE) were shown to have high contents of Rb3 and Rb2. Rb3, the major chemical components of PGLE, promoted collagen synthesis though the activation of transforming growth factor-β (TGF-β) in human skin fibroblast cells. In addition, the possibility of PGLE as an anti-skin-aging agent has also been clinically validated. Our analysis of the crow’s feet wrinkle showed that there was a decrease in the depth of deep furrows in the region of interest (RI) treated with PGLE lotion over an eight-week period. Based on these results, we suggest the possibility that PGLE, having high levels of Rb3, be considered as an attractive, wrinkle-reducing candidate for topical application. View Full-Text
Keywords: Panax ginseng leaf; ginsenoside Rb3; collagen synthesis; anti-wrinkle Panax ginseng leaf; ginsenoside Rb3; collagen synthesis; anti-wrinkle
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Shin, S.; Lee, J.-A.; Son, D.; Park, D.; Jung, E. Anti-Skin-Aging Activity of a Standardized Extract from Panax ginseng Leaves In Vitro and In Human Volunteer. Cosmetics 2017, 4, 18.

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