Development of Effervescent Cleansing Tablets Containing Asiatic-Acid-Loaded Solid Lipid Microparticles

Round 1

Reviewer 1 Report

1. In the title mentioned tablet contains SLMs but in the abstract nothing about it and its characterization methods Please see to it. 

2. Here author prepared SLMs ....so at the end of the experiment SLMs prepared properly or not their characterization parameters not mentioned here.

3. The discussion part will be more elaborated.

Comments for author File: Comments.pdf

Author Response

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Author Response File: Author Response.pdf

Reviewer 2 Report

Dear Authors,

I found this manuscript "Development of Effervescent Cleansing Tablets containing Asiatic Acid loaded Solid Lipid Microparticles" interesting, but I have several comments:

1. The list of references should be organized according to the requirements.
2. I suggest that you use the term selection instead of optimization since you did not apply experimental design with the aim of optimizing the search. Line 149
3. According to Table 1, citric acid was in all cases 100 mg, while sodium bicarbonate was less (87.45 mg) or more (109.31 mg and 131.18 mg). So the ratio between these materials should be 1.14:1, 1:1.09 and 1:1.31. How do you get the ratios 1:2, 1:2.5 and 1:3? Line 153
4. Why in one method you used a fixed compression pressure of 0.8 tons, and in another method, you already used a fixed compression force of 4–5 Kp. I propose to unify the units of force measurement. Lines 160 and 227
5. The standard deviation (SD) must be in parentheses (mean (SD)) because the standard error (SE) is given as ± (mean ± SE). I propose correcting it.
6. What membrane filter was used (eg nylon, PVDF or other)? It should be specified. Line 292
7. What was the elution mode (isocratic or gradient)? It should be specified. Line 296
8. What purpose was absolute ethanol used for? Is Asiatic acid poorly soluble in buffer? It should be explained. Lines 307–308
9. I suggest that you use the term selected tablet formulations instead of optimized tablet formulations. Line 357
10. You used one-way analysis of variance (ANOVA), and what post-hoc criterion did you use in this method? Line 370
11. You write "The moisture content of the powder blend before compression into tablets was between 0.18 ± 0.02% and 0.44 ± 0.03% in all formulations as presented in Table 5". Although it should be between 0.18±0.08% and 0.38±0.03% (Table 5). Line 432
12. Figures 3.B, 3.D is not provided in the text.
13. You write "Therefore, friability < 1% was acceptable for effervescent tablets". However in your case the friability of the tablets was above 1%. Lines 529, 533
14. Why is the amount of Asiatic acid released after 10 minutes very similar to that after 5 minutes, while a larger spike is observed after 15 minutes (Figure 4)? Why does the release process slow down after 5 minutes and then speed up again after 10 minutes?
15. You claim that the tested properties of the tablets during stability at 4˚C and 25˚C temperature did not change within 3 months, but the Figures (7.B, 8.A, 10.A and B, 11.A and B) show obvious changes.

Author Response

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Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

no comments

Reviewer 2 Report

Dear Authors,

thank you for taking my comments into account and correcting your manuscript