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Biology 2015, 4(4), 860-880; doi:10.3390/biology4040860

Fish Peroxiredoxins and Their Role in Immunity

1
Centro Oceanográfico de Murcia, Instituto Español de Oceanografía (IEO), Carretera de la Azohía s/n, Puerto de Mazarrón, Murcia 30860, Spain
2
Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional “Campus Mare Nostrum”, University of Murcia, Murcia 30100, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Brian Dixon
Received: 31 July 2015 / Revised: 4 November 2015 / Accepted: 19 November 2015 / Published: 27 November 2015
(This article belongs to the Special Issue Current Topics in Fish Immunity)
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Abstract

Peroxiredoxins (Prxs) are a family of antioxidant enzymes that protect cells from oxidative damage. In addition, Prxs may act as modulators of inflammation, protect against cell death and tumour progression, and facilitate tissue repair after damage. The most studied roles of Prx1 and Prx2 are immunological. Here we present a review on the effects of some immunostimulant treatments and bacterial, viral, or parasitic infections on the expression of fish Prxs at the gene and/or protein level, and point to their important role in immunity. The Prxs show antioxidant activity as well as a protective effect against infection. Some preliminary data are presented about the role of fish Prx1 and Prx2 in virus resistance although further studies are needed before the role of fish Prx in immunity can be definitively defined. View Full-Text
Keywords: peroxiredoxins; fish; immunity; antioxidant enzymes; natural killer enhancement factor; virus peroxiredoxins; fish; immunity; antioxidant enzymes; natural killer enhancement factor; virus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Valero, Y.; Martínez-Morcillo, F.J.; Esteban, M.Á.; Chaves-Pozo, E.; Cuesta, A. Fish Peroxiredoxins and Their Role in Immunity. Biology 2015, 4, 860-880.

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