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Open AccessCommunication
Fibers 2017, 5(4), 41; doi:10.3390/fib5040041

Tolnaftate-Loaded PolyacrylateElectrospun Nanofibers for an Impressive Regimen on Dermatophytosis

Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad 211007, India
Nanotechnology Application Centre, Institute of Interdisciplinary Studies, University of Allahabad, Allahabad 211002, India
E-Spin Nanotech Pvt. Ltd. SIDBI Centre, Indian Institute of Technology, Kanpur 208016, India
Author to whom correspondence should be addressed.
Academic Editor: Anil N. Netravali
Received: 10 July 2017 / Revised: 28 July 2017 / Accepted: 31 October 2017 / Published: 6 November 2017
(This article belongs to the Special Issue Nanofibers)
View Full-Text   |   Download PDF [4342 KB, uploaded 6 November 2017]   |  


Dermatophytosis, topical fungal infection is the most common cause of skin bug in the world, generally underestimated and ignored. It is commonly caused by immensely mortifying and keratinophilic fungal eukaryotes which invade keratinized tissues and generate different tinea diseases in Mediterranean countries. We herein fabricated nanofibers/scaffolds embedded with thiocarbamate derivative topical antifungal tolnaftatefor the first time to target the complete elimination of dermatophyte at the site of infection. In this regard, variable combinations of biocompatible Eudragit grades (ERL100 and ERS100) were selected to provide better adhesion on the site of dermatophytosis, ample absorption of exudates during treatment, and customized controlled drug release. Surface topography analysis indicated that the fabricated nanofibers were regular and defect-free, comprising distinct pockets with nanoscaled diameters. Characterization and compatibility studies of tolnaftate, polymers, and their nanofibers were performed through ATR-FTIR, TGA, and PXRD. Remarkable hydrophilicity and an excellent swelling index were obtained from a 3:1 ratio of ERL100/ERS100 electrospun D3 nanofibers, which is an essential benchmark for the fabrication of nanofibrous scaffolds for alleviating dermatophytosis. In vitro drug release investigation revealed that a nonwoven nanomesh of nanofibers could control the rate of drug release for 8 h. A microdilution assay exhibited inhibition of more than 95% viable cells of Trichophyton rubrum for 96 h. However, Microsporum species rigidly restricted the effect of bioactive antifungal nanofibers and hence showed resistance. In vivo activity on Trichophyton rubrum infected Swiss albino mice revealed complete inhibition of fungal pathogens on successive applications of D3 nanofibers for 7 days. This investigation suggests potential uses of tolnaftate loaded polyacrylate nanofibers as dressing materials/scaffolds for effective management of dermatophytosis. View Full-Text
Keywords: dermatophytosis; polyacrylate nanofibers; tolnaftate; dressing materials dermatophytosis; polyacrylate nanofibers; tolnaftate; dressing materials

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Misra, S.K.; Pandey, H.; Patil, S.; Ramteke, P.W.; Pandey, A.C. Tolnaftate-Loaded PolyacrylateElectrospun Nanofibers for an Impressive Regimen on Dermatophytosis. Fibers 2017, 5, 41.

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