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Coatings 2013, 3(2), 98-107; doi:10.3390/coatings3020098

Uniform and Robust Peptoid Microsphere Coatings

Ralph E. Martin Department of Chemical Engineering, University of Arkansas, 3202 Bell Engineering Center, Fayetteville, AR 72701, USA
* Author to whom correspondence should be addressed.
Received: 21 May 2013 / Revised: 13 June 2013 / Accepted: 14 June 2013 / Published: 21 June 2013
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Peptoids that are helical and partially water soluble have been shown to self-assemble into microspheres when the peptoid solution is dried on a silicon substrate. Such microsphere coatings have great potential for use in biosensor technologies, specifically to increase the surface area for binding. However, in order to be useful, the peptoids must consistently form uniform coatings. In this study we investigated the effects of various coating protocol parameters on the uniformity of the resulting peptoid microsphere coatings, including (i) solvent, (ii) administration technique, and (iii) drying environment. In addition, we investigated the robustness of the coatings as well as the potential for using a glass substrate. These studies show that uniform, robust peptoid microsphere coatings can be formed using protic solvents, a full coverage administration technique, and drying in open air on silicon or glass substrates.
Keywords: coating; biosensor; peptoid; microsphere coating; biosensor; peptoid; microsphere
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hebert, M.L.; Shah, D.S.; Blake, P.; Servoss, S.L. Uniform and Robust Peptoid Microsphere Coatings. Coatings 2013, 3, 98-107.

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