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Uniform and Robust Peptoid Microsphere Coatings
Ralph E. Martin Department of Chemical Engineering, University of Arkansas, 3202 Bell Engineering Center, Fayetteville, AR 72701, USA
* Author to whom correspondence should be addressed.
Received: 21 May 2013; in revised form: 13 June 2013 / Accepted: 14 June 2013 / Published: 21 June 2013
Abstract: Peptoids that are helical and partially water soluble have been shown to self-assemble into microspheres when the peptoid solution is dried on a silicon substrate. Such microsphere coatings have great potential for use in biosensor technologies, specifically to increase the surface area for binding. However, in order to be useful, the peptoids must consistently form uniform coatings. In this study we investigated the effects of various coating protocol parameters on the uniformity of the resulting peptoid microsphere coatings, including (i) solvent, (ii) administration technique, and (iii) drying environment. In addition, we investigated the robustness of the coatings as well as the potential for using a glass substrate. These studies show that uniform, robust peptoid microsphere coatings can be formed using protic solvents, a full coverage administration technique, and drying in open air on silicon or glass substrates.
Keywords: coating; biosensor; peptoid; microsphere
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MDPI and ACS Style
Hebert, M.L.; Shah, D.S.; Blake, P.; Servoss, S.L. Uniform and Robust Peptoid Microsphere Coatings. Coatings 2013, 3, 98-107.
Hebert ML, Shah DS, Blake P, Servoss SL. Uniform and Robust Peptoid Microsphere Coatings. Coatings. 2013; 3(2):98-107.
Hebert, Melissa L.; Shah, Dhaval S.; Blake, Phillip; Servoss, Shannon L. 2013. "Uniform and Robust Peptoid Microsphere Coatings." Coatings 3, no. 2: 98-107.