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Uniform and Robust Peptoid Microsphere Coatings
AbstractPeptoids that are helical and partially water soluble have been shown to self-assemble into microspheres when the peptoid solution is dried on a silicon substrate. Such microsphere coatings have great potential for use in biosensor technologies, specifically to increase the surface area for binding. However, in order to be useful, the peptoids must consistently form uniform coatings. In this study we investigated the effects of various coating protocol parameters on the uniformity of the resulting peptoid microsphere coatings, including (i) solvent, (ii) administration technique, and (iii) drying environment. In addition, we investigated the robustness of the coatings as well as the potential for using a glass substrate. These studies show that uniform, robust peptoid microsphere coatings can be formed using protic solvents, a full coverage administration technique, and drying in open air on silicon or glass substrates.
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Hebert, M.L.; Shah, D.S.; Blake, P.; Servoss, S.L. Uniform and Robust Peptoid Microsphere Coatings. Coatings 2013, 3, 98-107.View more citation formats
Hebert ML, Shah DS, Blake P, Servoss SL. Uniform and Robust Peptoid Microsphere Coatings. Coatings. 2013; 3(2):98-107.Chicago/Turabian Style
Hebert, Melissa L.; Shah, Dhaval S.; Blake, Phillip; Servoss, Shannon L. 2013. "Uniform and Robust Peptoid Microsphere Coatings." Coatings 3, no. 2: 98-107.