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Antibiotics 2017, 6(3), 15; https://doi.org/10.3390/antibiotics6030015

Comparative Study on Antistaphylococcal Activity of Lipopeptides in Various Culture Media

Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416 Gdańsk, Poland
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Author to whom correspondence should be addressed.
Academic Editor: Naresh Kumar
Received: 12 June 2017 / Revised: 17 July 2017 / Accepted: 31 July 2017 / Published: 2 August 2017
(This article belongs to the Special Issue Antibiotic Synthesis)
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Abstract

Staphylococcus aureus bacteria are one of the leading microorganisms responsible for nosocomial infections as well as being the primary causative pathogen of skin and wound infections. Currently, the therapy of staphylococcal diseases faces many difficulties, due to a variety of mechanisms of resistance and virulence factors. Moreover, a number of infections caused by S. aureus are connected with biofilm formation that impairs effectiveness of the therapy. Short cationic lipopeptides that are designed on the basis of the structure of antimicrobial peptides are likely to provide a promising alternative to conventional antibiotics. Many research groups have proved a high antistaphylococcal potential of lipopeptides, however, the use of different protocols for determination of antimicrobial activity may be the reason for inconsistency of the results. The aim of this study was to learn how the use of various bacteriological media as well as solvents may affect activity of lipopeptides and their cyclic analogs. Obtained results showed a great impact of these variables. For example, cyclic analogs were more effective when dissolved in an aqueous solution of acetic acid and bovine serum albumin (BSA). The greater activity against planktonic cultures was found in brain-heart infusion broth (BHI) and tryptic-soy broth (TSB), while the antibiofilm activity was higher in the Mueller-Hinton medium. View Full-Text
Keywords: antimicrobial peptides; lipopeptides; cyclic lipopeptides; Staphylococcus aureus; biofilm; culture media antimicrobial peptides; lipopeptides; cyclic lipopeptides; Staphylococcus aureus; biofilm; culture media
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Jaśkiewicz, M.; Neubauer, D.; Kamysz, W. Comparative Study on Antistaphylococcal Activity of Lipopeptides in Various Culture Media. Antibiotics 2017, 6, 15.

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