Next Article in Journal / Special Issue
Comparative Study on Antistaphylococcal Activity of Lipopeptides in Various Culture Media
Previous Article in Journal / Special Issue
Antibacterial Activity and Toxicity of Analogs of Scorpion Venom IsCT Peptides
Article Menu

Export Article

Open AccessReview
Antibiotics 2017, 6(3), 14; https://doi.org/10.3390/antibiotics6030014

Macromolecular Conjugate and Biological Carrier Approaches for the Targeted Delivery of Antibiotics

Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543, Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Naresh Kumar
Received: 30 May 2017 / Revised: 24 June 2017 / Accepted: 29 June 2017 / Published: 4 July 2017
(This article belongs to the Special Issue Antibiotic Synthesis)
View Full-Text   |   Download PDF [2124 KB, uploaded 6 July 2017]   |  

Abstract

For the past few decades, the rapid rise of antibiotic multidrug-resistance has presented a palpable threat to human health worldwide. Meanwhile, the number of novel antibiotics released to the market has been steadily declining. Therefore, it is imperative that we utilize innovative approaches for the development of antimicrobial therapies. This article will explore alternative strategies, namely drug conjugates and biological carriers for the targeted delivery of antibiotics, which are often eclipsed by their nanomedicine-based counterparts. A variety of macromolecules have been investigated as conjugate carriers, but only those most widely studied in the field of infectious diseases (e.g., proteins, peptides, antibodies) will be discussed in detail. For the latter group, blood cells, especially erythrocytes, have been successfully tested as homing carriers of antimicrobial agents. Bacteriophages have also been studied as a candidate for similar functions. Once these alternative strategies receive the amount of research interest and resources that would more accurately reflect their latent applicability, they will inevitably prove valuable in the perennial fight against antibiotic resistance. View Full-Text
Keywords: targeted delivery; antibiotic resistance; macromolecular conjugate; prodrug; erythrocyte carrier; bacteriophage carrier targeted delivery; antibiotic resistance; macromolecular conjugate; prodrug; erythrocyte carrier; bacteriophage carrier
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Tram, N.D.T.; Ee, P.L.R. Macromolecular Conjugate and Biological Carrier Approaches for the Targeted Delivery of Antibiotics. Antibiotics 2017, 6, 14.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top