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Antibiotics 2015, 4(4), 653-666; doi:10.3390/antibiotics4040653

Examining the Clinical Effectiveness of Non-Carbapenem β-Lactams for the Treatment of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae

1
Department of Pharmacy, Froedtert & The Medical College of Wisconsin, 9200 W. Wisconsin Ave, Milwaukee, WI 53226, USA
2
Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, 833 S. Wood St., 164 PHARM, Chicago, IL 60612, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Christopher Butler
Received: 8 October 2015 / Revised: 20 November 2015 / Accepted: 8 December 2015 / Published: 15 December 2015
(This article belongs to the Special Issue Antimicrobial Stewardship)
View Full-Text   |   Download PDF [699 KB, uploaded 15 December 2015]

Abstract

Treatment options for extended-spectrum β-lactamase-producing Enterobacteriaceae are limited. Piperacillin-tazobactam and cefepime represent potential alternative treatment options; however, large prospective studies are lacking. This review evaluates the current literature regarding use of piperacillin-tazobactam and cefepime for the treatment of extended-spectrum β-lactamase-producing Enterobacteriaceae. Antimicrobial stewardship programs can play a key role in guiding the best practices for the management of these challenging infections. View Full-Text
Keywords: extended-spectrum beta-lactamases; piperacillin-tazobactam; cefepime; carbapenems extended-spectrum beta-lactamases; piperacillin-tazobactam; cefepime; carbapenems
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gibble, A.M.; Gross, A.E.; Huang, A.M. Examining the Clinical Effectiveness of Non-Carbapenem β-Lactams for the Treatment of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae. Antibiotics 2015, 4, 653-666.

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