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Open AccessCommunication
Antibiotics 2015, 4(3), 321-328; doi:10.3390/antibiotics4030321

Participation of S. Typhimurium cysJIH Operon in the H2S-mediated Ciprofloxacin Resistance in Presence of Sulfate as Sulfur Source

1
Laboratorio de Genética y Patogénesis Bacteriana, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Universidad Andres Bello, República 217, Santiago 8370146, Chile
2
Center for Integrative Medicine and Innovative Science, Facultad de Medicina, Universidad Andres Bello, Echaurren 183, Santiago 8370071, Chile
3
Laboratorio de Microbiología, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Universidad Andres Bello, República 217, Santiago 8370146, Chile
4
Gut Microbiota and Clostridia Research Group, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Universidad Andres Bello, República 217, Santiago 837014, Chile
*
Author to whom correspondence should be addressed.
Academic Editor: Christopher C. Butler
Received: 18 June 2015 / Revised: 22 July 2015 / Accepted: 27 July 2015 / Published: 31 July 2015
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Abstract

H2S production has been proposed as a mechanism to explain bacterial resistance to antibiotics. In this work, we present evidence for the role of the cysJIH operon in resistance to ciprofloxacin mediated by H2S production with different sulfate as the only sulfur source. We found that the products of the cysJIH operon are involved in ciprofloxacin resistance by increasing both, the levels of H2S and reduced thiols apparently counteracting antimicrobial-induced reactive oxygen species (ROS). This protective effect was observed only when bacteria were cultured in the presence of sulfate, but not with cysteine, as the sole sulfur source. View Full-Text
Keywords: cysJIH; ciprofloxacin resistance; H2S production; sulfate; sulfur source cysJIH; ciprofloxacin resistance; H2S production; sulfate; sulfur source
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Álvarez, R.; Frávega, J.; Rodas, P.I.; Fuentes, J.A.; Paredes-Sabja, D.; Calderón, I.L.; Gil, F. Participation of S. Typhimurium cysJIH Operon in the H2S-mediated Ciprofloxacin Resistance in Presence of Sulfate as Sulfur Source. Antibiotics 2015, 4, 321-328.

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