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The Effects of Two Novel Copper-Based Formulations on Helicobacter pylori
First Medical Clinic, University of Bologna, Bologna 40121, Italy
Department of Health & Social Sciences, University of Middlesex, NW4 4Bt London, UK
* Author to whom correspondence should be addressed.
Received: 30 March 2013; in revised form: 1 May 2013 / Accepted: 7 May 2013 / Published: 21 May 2013
Abstract: We investigated the effects of two novel copper-based inorganic formulations for their activity against 60 isolates of Helicobacter pylori (Hp). The two copper-based formulations were tested against three NCTC Helicobacter pylori isolates and 57 clinical strains isolated from the UK and Italy in time-kill assays. Both copper-based formulations were bio-cidal against all Helicobacter pylori strains tested reducing the viable count by 4–5 log within 2 h. These two copper-based anti-microbial agents deserve further study in relation to the treatment of H. pylori-related gastric disease.
Keywords: bactericidal; copper; helicobacter; novel formulation
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MDPI and ACS Style
Saracino, I.M.; Zaccaro, C.; Re, G.L.; Vaira, D.; Holton, J. The Effects of Two Novel Copper-Based Formulations on Helicobacter pylori. Antibiotics 2013, 2, 265-273.
Saracino IM, Zaccaro C, Re GL, Vaira D, Holton J. The Effects of Two Novel Copper-Based Formulations on Helicobacter pylori. Antibiotics. 2013; 2(2):265-273.
Saracino, Ilaria M.; Zaccaro, Cristina; Re, Giovanna L.; Vaira, Dino; Holton, John. 2013. "The Effects of Two Novel Copper-Based Formulations on Helicobacter pylori." Antibiotics 2, no. 2: 265-273.