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Biosensors 2017, 7(4), 60; https://doi.org/10.3390/bios7040060

Spontaneous Charge Generation in Flowing Albumin Solutions at 35 °C and 38 °C

Institute of Biomedical Chemistry, 119121 Moscow, Russia
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Received: 21 October 2017 / Revised: 1 December 2017 / Accepted: 4 December 2017 / Published: 11 December 2017
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Abstract

The time dependence of a charge accumulation in a 10−15 M albumin solution, flowing through a measuring cell of an analytical flow system injector, had a nonlinear character under certain conditions, within a human physiological temperature range. Sharp charge increases depended on albumin concentration. This effect must be taken into consideration when generating models that describe electrokinetic phenomena in flowing protein solutions and when developing analytical flow systems for the registration of biomolecules in low concentration ranges. View Full-Text
Keywords: analytical flow-through systems; flowing protein solution; charge accumulation; serum albumin; physiological temperature analytical flow-through systems; flowing protein solution; charge accumulation; serum albumin; physiological temperature
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Ivanov, Y.D.; Kozlov, A.F.; Galiullin, R.A.; Kolesanova, E.F.; Pleshakova, T.O. Spontaneous Charge Generation in Flowing Albumin Solutions at 35 °C and 38 °C. Biosensors 2017, 7, 60.

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