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Biosensors 2017, 7(3), 30; doi:10.3390/bios7030030

Point-of-Care-Testing in Acute Stroke Management: An Unmet Need Ripe for Technological Harvest

1
Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
2
School of Material Science & Engineering, Nanyang Technology University, 50 Nanyang Avenue, Singapore 639798, Singapore
3
Institute for Sports Research (ISR), Nanyang Technology University and Loughborough University, Nanyang Avenue, Singapore 639798, Singapore
4
Agriculture Research Organization (ARO), Volcani Centre, Rishon LeTsiyon 15159, Israel
5
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, 1E Kent Ridge Road, Singapore 119228, Singapore
6
The National Institute for Biotechnology in the Negev, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
7
The Ilse Katz Centre for Meso and Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel
*
Authors to whom correspondence should be addressed.
Received: 4 July 2017 / Revised: 25 July 2017 / Accepted: 26 July 2017 / Published: 3 August 2017
(This article belongs to the Special Issue Point-of-Care Diagnostics)
View Full-Text   |   Download PDF [2124 KB, uploaded 7 August 2017]   |  

Abstract

Stroke, the second highest leading cause of death, is caused by an abrupt interruption of blood to the brain. Supply of blood needs to be promptly restored to salvage brain tissues from irreversible neuronal death. Existing assessment of stroke patients is based largely on detailed clinical evaluation that is complemented by neuroimaging methods. However, emerging data point to the potential use of blood-derived biomarkers in aiding clinical decision-making especially in the diagnosis of ischemic stroke, triaging patients for acute reperfusion therapies, and in informing stroke mechanisms and prognosis. The demand for newer techniques to deliver individualized information on-site for incorporation into a time-sensitive work-flow has become greater. In this review, we examine the roles of a portable and easy to use point-of-care-test (POCT) in shortening the time-to-treatment, classifying stroke subtypes and improving patient’s outcome. We first examine the conventional stroke management workflow, then highlight situations where a bedside biomarker assessment might aid clinical decision-making. A novel stroke POCT approach is presented, which combines the use of quantitative and multiplex POCT platforms for the detection of specific stroke biomarkers, as well as data-mining tools to drive analytical processes. Further work is needed in the development of POCTs to fulfill an unmet need in acute stroke management. View Full-Text
Keywords: Stroke; Diagnostics; Point-of-Care-Test; Biomarkers; Time-Dependent Treatment; Multiplex and Quantitative Detection; Data-Mining Stroke; Diagnostics; Point-of-Care-Test; Biomarkers; Time-Dependent Treatment; Multiplex and Quantitative Detection; Data-Mining
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Harpaz, D.; Eltzov, E.; Seet, R.C.; Marks, R.S.; Tok, A.I. Point-of-Care-Testing in Acute Stroke Management: An Unmet Need Ripe for Technological Harvest. Biosensors 2017, 7, 30.

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