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Biosensors 2017, 7(2), 19; doi:10.3390/bios7020019

A Label-Free, Quantitative Fecal Hemoglobin Detection Platform for Colorectal Cancer Screening

1
Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Victoria 3050, Australia
2
Department of Biochemistry, Faculty of Medicine, Hasanuddin University, South Sulawesi 90245, Indonesia
3
Centre for Neural Engineering, The University of Melbourne, Carlton, VIC 3053, Australia
4
Department of Electrical and Electronic Engineering, Melbourne School of Engineering, The University of Melbourne, Victoria 3010, Australia
5
Department of Psychiatry, Royal Melbourne Hospital, The University of Melbourne, Victoria 3050, Australia
These authors made equal contribution.
*
Authors to whom correspondence should be addressed.
Academic Editor: Jeff D. Newman
Received: 31 March 2017 / Revised: 2 May 2017 / Accepted: 3 May 2017 / Published: 5 May 2017
(This article belongs to the Special Issue Point-of-Care Diagnostics)
View Full-Text   |   Download PDF [3034 KB, uploaded 5 May 2017]   |  

Abstract

The early detection of colorectal cancer is vital for disease management and patient survival. Fecal hemoglobin detection is a widely-adopted method for screening and early diagnosis. Fecal Immunochemical Test (FIT) is favored over the older generation chemical based Fecal Occult Blood Test (FOBT) as it does not require dietary or drug restrictions, and is specific to human blood from the lower digestive tract. To date, no quantitative FIT platforms are available for use in the point-of-care setting. Here, we report proof of principle data of a novel low cost quantitative fecal immunochemical-based biosensor platform that may be further developed into a point-of-care test in low-resource settings. The label-free prototype has a lower limit of detection (LOD) of 10 µg hemoglobin per gram (Hb/g) of feces, comparable to that of conventional laboratory based quantitative FIT diagnostic systems. View Full-Text
Keywords: biosensors; immunosensor; interdigitated electrodes; colorectal cancer; screening; impedance; point of care; label-free; diagnostics biosensors; immunosensor; interdigitated electrodes; colorectal cancer; screening; impedance; point of care; label-free; diagnostics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Soraya, G.V.; Nguyen, T.C.; Abeyrathne, C.D.; Huynh, D.H.; Chan, J.; Nguyen, P.D.; Nasr, B.; Chana, G.; Kwan, P.; Skafidas, E. A Label-Free, Quantitative Fecal Hemoglobin Detection Platform for Colorectal Cancer Screening. Biosensors 2017, 7, 19.

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