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Biosensors 2017, 7(3), 27; doi:10.3390/bios7030027

A Label-Free and Ultrasensitive Immunosensor for Detection of Human Chorionic Gonadotrophin Based on Graphene FETs

Wolfson Nanomaterials and Devices Laboratory, School of Computing, Electronics and Mathematics, Faculty of Science and Engineering, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK
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Received: 1 June 2017 / Revised: 24 June 2017 / Accepted: 3 July 2017 / Published: 12 July 2017
(This article belongs to the Special Issue Biosensors for the Detection of Biomarkers)
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Abstract

We report on a label-free immunosensor based on graphene field effect transistors (G-FETs) for the ultrasensitive detection of Human Chorionic Gonadotrophin (hCG), as an indicator of pregnancy and related disorders, such as actopic pregnancy, choriocarcinoma and orchic teratoma. Pyrene based bioactive ester was non-covalently anchored onto the graphene channel in order to retain the sp2 lattice. The G-FET transfer characteristics showed repeatable and reliable responses in all surface modifying steps using a direct current (DC) readout system. The hCG concentration gradient showed a detection limit of ~1 pg·mL−1. The proposed method facilitates the cost-effective and viable production of graphene point-of-care devices for clinical diagnosis. View Full-Text
Keywords: graphene; field effect transistor; immunosensor; human chorionic gonadotrophin graphene; field effect transistor; immunosensor; human chorionic gonadotrophin
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Islam, K.; Suhail, A.; Pan, G. A Label-Free and Ultrasensitive Immunosensor for Detection of Human Chorionic Gonadotrophin Based on Graphene FETs. Biosensors 2017, 7, 27.

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