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Biosensors 2016, 6(4), 53; doi:10.3390/bios6040053

Biofouling-Resistant Impedimetric Sensor for Array High-Resolution Extracellular Potassium Monitoring in the Brain

1
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada
2
Toronto Western Research Institute, Fundamental Neurobiology Division, 60 Leonard Avenue, Toronto, ON M5T 2S8, Canada
3
Department of Electrical and Computer Engineering, University of Toronto, 10 King’s College Road, Toronto, ON M5S 3G4, Canada
4
Institute of Biomaterials & Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada
*
Authors to whom correspondence should be addressed.
Academic Editor: Hargsoon Yoon
Received: 16 July 2016 / Revised: 28 September 2016 / Accepted: 30 September 2016 / Published: 13 October 2016
(This article belongs to the Special Issue Neural Sensing and Interfacing Technology)
View Full-Text   |   Download PDF [2312 KB, uploaded 13 October 2016]   |  

Abstract

Extracellular potassium concentration, [K+]o, plays a fundamental role in the physiological functions of the brain. Studies investigating changes in [K+]o have predominantly relied upon glass capillary electrodes with K+-sensitive solution gradients for their measurements. However, such electrodes are unsuitable for taking spatio-temporal measurements and are limited by the surface area of their tips. We illustrate seizures invoked chemically and in optogenetically modified mice using blue light exposure while impedimetrically measuring the response. A sharp decrease of 1–2 mM in [K+]o before each spike has shown new physiological events not witnessed previously when measuring extracellular potassium concentrations during seizures in mice. We propose a novel approach that uses multichannel monolayer coated gold microelectrodes for in vivo spatio-temporal measurements of [K+]o in a mouse brain as an improvement to the conventional glass capillary electrode. View Full-Text
Keywords: biosensor; electrodes; potassium; anti-fouling; seizure; impedance biosensor; electrodes; potassium; anti-fouling; seizure; impedance
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MDPI and ACS Style

Machado, R.; Soltani, N.; Dufour, S.; Salam, M.T.; Carlen, P.L.; Genov, R.; Thompson, M. Biofouling-Resistant Impedimetric Sensor for Array High-Resolution Extracellular Potassium Monitoring in the Brain. Biosensors 2016, 6, 53.

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