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Biosensors 2016, 6(1), 7; doi:10.3390/bios6010007

Comparison of Electrochemical Immunosensors and Aptasensors for Detection of Small Organic Molecules in Environment, Food Safety, Clinical and Public Security

University Paris Diderot, Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS, 15 rue J-A de Baïf, Paris 75205, France
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editors: Nicole Jaffrezic-Renault and Carole Chaix
Received: 22 December 2015 / Revised: 16 February 2016 / Accepted: 19 February 2016 / Published: 29 February 2016
(This article belongs to the Special Issue Affinity Sensors)
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Abstract

We review here the most frequently reported targets among the electrochemical immunosensors and aptasensors: antibiotics, bisphenol A, cocaine, ochratoxin A and estradiol. In each case, the immobilization procedures are described as well as the transduction schemes and the limits of detection. It is shown that limits of detections are generally two to three orders of magnitude lower for immunosensors than for aptasensors, due to the highest affinities of antibodies. No significant progresses have been made to improve these affinities, but transduction schemes were improved instead, which lead to a regular improvement of the limit of detections corresponding to ca. five orders of magnitude over these last 10 years. These progresses depend on the target, however. View Full-Text
Keywords: immunosensor; aptasensor; ciprofloxacin; enrofloxacin; ofloxacin; tetracyclines; neomycin; tobramycin; ampicillin; kanamycin; sulfonamides; bisphenol A; cocaine; ochratoxin A; estradiol immunosensor; aptasensor; ciprofloxacin; enrofloxacin; ofloxacin; tetracyclines; neomycin; tobramycin; ampicillin; kanamycin; sulfonamides; bisphenol A; cocaine; ochratoxin A; estradiol
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Piro, B.; Shi, S.; Reisberg, S.; Noël, V.; Anquetin, G. Comparison of Electrochemical Immunosensors and Aptasensors for Detection of Small Organic Molecules in Environment, Food Safety, Clinical and Public Security. Biosensors 2016, 6, 7.

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