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Biosensors 2016, 6(1), 8; doi:10.3390/bios6010008

Aryl Diazonium Chemistry for the Surface Functionalization of Glassy Biosensors

1
Department of Electrical and Computer Engineering, University of Alberta, Edmonton, Alberta, AB T6G 2V4, Canada
2
Department of Chemistry and National Institute for Nanotechnology, University of Alberta, Edmonton, Alberta, AB T6G 2G2, Canada
3
Department of Experimental Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, AB T6G 1Z2, Canada
4
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, AB T6G 1H9, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Ebrahim Ghafar-Zadeh
Received: 2 February 2016 / Revised: 7 March 2016 / Accepted: 9 March 2016 / Published: 14 March 2016
(This article belongs to the Special Issue Micro- and Nano-Bio-Interfaces)
View Full-Text   |   Download PDF [4470 KB, uploaded 14 March 2016]   |  

Abstract

Nanostring resonator and fiber-optics-based biosensors are of interest as they offer high sensitivity, real-time measurements and the ability to integrate with electronics. However, these devices are somewhat impaired by issues related to surface modification. Both nanostring resonators and photonic sensors employ glassy materials, which are incompatible with electrochemistry. A surface chemistry approach providing strong and stable adhesion to glassy surfaces is thus required. In this work, a diazonium salt induced aryl film grafting process is employed to modify a novel SiCN glassy material. Sandwich rabbit IgG binding assays are performed on the diazonium treated SiCN surfaces. Fluorescently labelled anti-rabbit IgG and anti-rabbit IgG conjugated gold nanoparticles were used as markers to demonstrate the absorption of anti-rabbit IgG and therefore verify the successful grafting of the aryl film. The results of the experiments support the effectiveness of diazonium chemistry for the surface functionalization of SiCN surfaces. This method is applicable to other types of glassy materials and potentially can be expanded to various nanomechanical and optical biosensors. View Full-Text
Keywords: biosensors; glasses; optical fibers; nanostrings; diazonium; surface linkers biosensors; glasses; optical fibers; nanostrings; diazonium; surface linkers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zheng, W.; van den Hurk, R.; Cao, Y.; Du, R.; Sun, X.; Wang, Y.; McDermott, M.T.; Evoy, S. Aryl Diazonium Chemistry for the Surface Functionalization of Glassy Biosensors. Biosensors 2016, 6, 8.

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