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Biosensors 2014, 4(1), 47-62; doi:10.3390/bios4010047
Review

Sensing a Sensor: Identifying the Mechanosensory Function of Primary Cilia

1,2
, 1,2
 and 1,2,*
Received: 3 January 2014; in revised form: 24 February 2014 / Accepted: 7 March 2014 / Published: 13 March 2014
(This article belongs to the Special Issue Sensors and Analytics for Cell Biology and Tissue Engineering)
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Abstract: Over the past decade, primary cilia have emerged as the premier means by which cells sense and transduce mechanical stimuli. Primary cilia are sensory organelles that have been shown to be vitally involved in the mechanosensation of urine in the renal nephron, bile in the hepatic biliary system, digestive fluid in the pancreatic duct, dentin in dental pulp, lacunocanalicular fluid in bone and cartilage, and blood in vasculature. The prevalence of primary cilia among mammalian cell types is matched by the tremendously varied disease states caused by both structural and functional defects in cilia. In the process of delineating the mechanisms behind these disease states, calcium fluorimetry has been widely utilized as a means of quantifying ciliary function to both fluid flow and pharmacological agents. In this review, we will discuss the approaches used in associating calcium levels to cilia function.
Keywords: cilia; calcium signaling; shear stress; cell culture; tissue; perfusion cilia; calcium signaling; shear stress; cell culture; tissue; perfusion
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Prasad, R.M.; Jin, X.; Nauli, S.M. Sensing a Sensor: Identifying the Mechanosensory Function of Primary Cilia. Biosensors 2014, 4, 47-62.

AMA Style

Prasad RM, Jin X, Nauli SM. Sensing a Sensor: Identifying the Mechanosensory Function of Primary Cilia. Biosensors. 2014; 4(1):47-62.

Chicago/Turabian Style

Prasad, Rahul M.; Jin, Xingjian; Nauli, Surya M. 2014. "Sensing a Sensor: Identifying the Mechanosensory Function of Primary Cilia." Biosensors 4, no. 1: 47-62.

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