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Nanomaterials 2017, 7(9), 268;

In Vitro Sonodynamic Therapeutic Effect of Polyion Complex Micelles Incorporating Titanium Dioxide Nanoparticles

Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan
Author to whom correspondence should be addressed.
Received: 1 August 2017 / Revised: 28 August 2017 / Accepted: 6 September 2017 / Published: 11 September 2017
(This article belongs to the Special Issue ZnO and TiO2 Based Nanostructures)
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Titanium dioxide nanoparticles (TiO2 NPs) can act as sonosensitizers, generating reactive oxygen species under ultrasound irradiation, for use in sonodynamic therapy. For TiO2 NPs delivery, we prepared polyion complex micelles incorporating TiO2 NPs (TiO2 NPs-PIC micelles) by mixing TiO2 NPs with polyallylamine bearing poly(ethylene glycol) grafts. In this study, the effects of polymer composition and ultrasound irradiation conditions on the sonodynamic therapeutic effect toward HeLa cells were evaluated experimentally using cell viability evaluation, intracellular distribution observation, and a cell staining assay. TiO2 NPs-PIC micelles with widely distributed features induced a significant decrease in cell viability under ultrasound irradiation. Furthermore, prolonging the irradiation time killed cells more effectively than did increasing the ultrasound power. The combination of TiO2 NP-PIC micelles and ultrasound irradiation was confirmed to induce apoptotic cell death. View Full-Text
Keywords: Titanium dioxide nanoparticles; sonodynamic therapy; polyion complex micelles Titanium dioxide nanoparticles; sonodynamic therapy; polyion complex micelles

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Yamamoto, S.; Ono, M.; Yuba, E.; Harada, A. In Vitro Sonodynamic Therapeutic Effect of Polyion Complex Micelles Incorporating Titanium Dioxide Nanoparticles. Nanomaterials 2017, 7, 268.

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