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Nanomaterials 2017, 7(8), 215; doi:10.3390/nano7080215

Application of Metal-Organic Framework Nano-MIL-100(Fe) for Sustainable Release of Doxycycline and Tetracycline

School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran
Chemistry & Chemical Engineering Research Center of Iran (CCERCI), Pajoohesh Blvd., km 17, Karaj Hwy, P.O. Box 14968-13151, Tehran, Iran
Author to whom correspondence should be addressed.
Received: 30 June 2017 / Revised: 1 August 2017 / Accepted: 1 August 2017 / Published: 6 August 2017
(This article belongs to the Special Issue Nanoparticles in Metal-Organic Frameworks)
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Nanostructures of MIL-100 were synthesized and used as a drug delivery platform for two members of the Tetracycline family. Doxycycline monohydrate (DOX) and Tetracycline hydrochloride (TC) were loaded separately on nano-MIL-100 (nanoparticles of drug@carrier were abbreviated as DOX@MIL-100 and TC@MIL-100). Characterizations were carried out using FT-IR, XRD, BET, DLS, and SEM. The FT-IR spectra revealed that the drugs were loaded into the framework of the carrier. The XRD patterns of DOX@MIL-100 and TC@MIL-100 indicated that no free DOX or TC were present. It could be concluded that the drugs are well dispersed into the pores of nano-MIL-100. The microporosity of the carrier was confirmed by BJH data. BET analysis showed a reduction in the free surface for both DOX@MIL-100 and TC@MIL-100. The release of TC and DOX was investigated, and it was revealed that MIL-100 mediated the drug solubility in water, which in turn resulted in a decrease in the release rate of TC (accelerating in DOX case) without lowering the total amount of released drug. After 48 h, 96 percent of the TC was sustain released, which is an unprecedented amount in comparison with other methods. View Full-Text
Keywords: doxycycline monohydrate; drug delivery; nano-MIL-100; sustain release; Tetracycline hydrochloride doxycycline monohydrate; drug delivery; nano-MIL-100; sustain release; Tetracycline hydrochloride

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Taherzade, S.D.; Soleimannejad, J.; Tarlani, A. Application of Metal-Organic Framework Nano-MIL-100(Fe) for Sustainable Release of Doxycycline and Tetracycline. Nanomaterials 2017, 7, 215.

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