Next Article in Journal
ZnO Nano-Rod Devices for Intradermal Delivery and Immunization
Previous Article in Journal
Highly Sensitive Magnetic-SERS Dual-Function Silica Nanoprobes for Effective On-Site Organic Chemical Detection
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle
Nanomaterials 2017, 7(6), 145; doi:10.3390/nano7060145

Microgroove and Collagen-poly(ε-caprolactone) Nanofiber Mesh Coating Improves the Mechanical Stability and Osseointegration of Titanium Implants

1
Department of Engineering & Physics, University of Central Oklahoma, Edmond, OK 73034, USA
2
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73034, USA
3
Veterans Affairs Department, Oklahoma City, OK 73105, USA, roman.wolf@va.gov
*
Author to whom correspondence should be addressed.
Academic Editor: Luigi Torre
Received: 26 April 2017 / Revised: 23 May 2017 / Accepted: 30 May 2017 / Published: 13 June 2017
View Full-Text   |   Download PDF [7900 KB, uploaded 13 June 2017]   |  

Abstract

The effect of depositing a collagen (CG)-poly-ε-caprolactone (PCL) nanofiber mesh (NFM) at the microgrooves of titanium (Ti) on the mechanical stability and osseointegration of the implant with bone was investigated using a rabbit model. Three groups of Ti samples were produced: control Ti samples where there were no microgrooves or CG-PCL NFM, groove Ti samples where microgrooves were machined on the circumference of Ti, and groove-NFM Ti samples where CG-PCL NFM was deposited on the machined microgrooves. Each group of Ti samples was implanted in the rabbit femurs for eight weeks. The mechanical stability of the Ti/bone samples were quantified by shear strength from a pullout tension test. Implant osseointegration was evaluated by a histomorphometric analysis of the percentage of bone and connective tissue contact with the implant surface. The bone density around the Ti was measured by micro–computed tomography (μCT) analysis. This study found that the shear strength of groove-NFM Ti/bone samples was significantly higher compared to control and groove Ti/bone samples (p < 0.05) and NFM coating influenced the bone density around Ti samples. In vivo histomorphometric analyses show that bone growth into the Ti surface increased by filling the microgrooves with CG-PCL NFM. The study concludes that a microgroove assisted CG-PCL NFM coating may benefit orthopedic implants. View Full-Text
Keywords: titanium; bone; shear strength; in vivo study; electrospun nanofiber titanium; bone; shear strength; in vivo study; electrospun nanofiber
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Khandaker, M.; Riahinezhad, S.; Williams, W.R.; Wolf, R. Microgroove and Collagen-poly(ε-caprolactone) Nanofiber Mesh Coating Improves the Mechanical Stability and Osseointegration of Titanium Implants. Nanomaterials 2017, 7, 145.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top