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Nanomaterials 2017, 7(6), 122; doi:10.3390/nano7060122

A Review of the Structure, Preparation, and Application of NLCs, PNPs, and PLNs

1
College of Pharmacy, Jinan University, Guangzhou 510632, China
2
College of Life Sciences, Liaoning University, Shenyang 110036, China
3
GuangzhouGuoyu Pharmaceutical Technology Co., Ltd., Guangzhou 510632, China
4
Division of Cancer Biology and Genetics, Queen’s University Cancer Research Institute, Kingston, ON K7L 3N6, Canada
5
Cancer Research Institute of Jinan University, Guangzhou 510632, China
The authors contribute equally to the work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Yoshihiro Ito
Received: 23 March 2017 / Revised: 9 May 2017 / Accepted: 16 May 2017 / Published: 27 May 2017
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Abstract

Nanostructured lipid carriers (NLCs) are modified solid lipid nanoparticles (SLNs) that retain the characteristics of the SLN, improve drug stability and loading capacity, and prevent drug leakage. Polymer nanoparticles (PNPs) are an important component of drug delivery. These nanoparticles can effectively direct drug delivery to specific targets and improve drug stability and controlled drug release. Lipid–polymer nanoparticles (PLNs), a new type of carrier that combines liposomes and polymers, have been employed in recent years. These nanoparticles possess the complementary advantages of PNPs and liposomes. A PLN is composed of a core–shell structure; the polymer core provides a stable structure, and the phospholipid shell offers good biocompatibility. As such, the two components increase the drug encapsulation efficiency rate, facilitate surface modification, and prevent leakage of water-soluble drugs. Hence, we have reviewed the current state of development for the NLCs’, PNPs’, and PLNs’ structures, preparation, and applications over the past five years, to provide the basis for further study on a controlled release drug delivery system. View Full-Text
Keywords: nanostructured lipid carriers; polymeric nanoparticles; lipid–polymer hybrid nanoparticles; structure; preparation; applications nanostructured lipid carriers; polymeric nanoparticles; lipid–polymer hybrid nanoparticles; structure; preparation; applications
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MDPI and ACS Style

Li, Q.; Cai, T.; Huang, Y.; Xia, X.; Cole, S.P.C.; Cai, Y. A Review of the Structure, Preparation, and Application of NLCs, PNPs, and PLNs. Nanomaterials 2017, 7, 122.

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