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Nanomaterials 2017, 7(3), 70; doi:10.3390/nano7030070

Melanin-Associated Synthesis of SERS-Active Nanostructures and the Application for Monitoring of Intracellular Melanogenesis

SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology, College of Biophotonics, South China Normal University, Guangzhou 510631, China
Infinitus (China) Company Ltd., Guangzhou 510665, China
Authors to whom correspondence should be addressed.
Academic Editors: Yuying Zhang and Wei Xie
Received: 23 December 2016 / Revised: 11 March 2017 / Accepted: 14 March 2017 / Published: 20 March 2017
(This article belongs to the Special Issue Nanomaterials for SERS Applications)
View Full-Text   |   Download PDF [3139 KB, uploaded 20 March 2017]   |  


Melanin plays an indispensable role in the human body. It serves as a biological reducer for the green synthesis of precious metal nanoparticles. Melanin–Ag nanocomposites were successfully produced which exhibited very strong surface-enhanced Raman scattering (SERS) effect because of the reducibility property of melanin. A melanin–Ag composite structure was synthesized in situ in melanin cells, and SERS technique was performed for the rapid imaging and quantitative assay of intracellular melanin. This imaging technique was also used to successfully trace the formation and secretion of intracellular melanin after stimulation with melanin-stimulating hormones. Based on the self-reducing property of melanin, the proposed SERS imaging method can provide potentially powerful analytical detection tools to study the biological functions of melanin and to prevent and cure melanin-related diseases. View Full-Text
Keywords: surface-enhanced Raman scattering; melanin–Ag nanocomposites; bioimaging; melanogenesis surface-enhanced Raman scattering; melanin–Ag nanocomposites; bioimaging; melanogenesis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Dong, H.; Liu, Z.; Zhong, H.; Yang, H.; Zhou, Y.; Hou, Y.; Long, J.; Lin, J.; Guo, Z. Melanin-Associated Synthesis of SERS-Active Nanostructures and the Application for Monitoring of Intracellular Melanogenesis. Nanomaterials 2017, 7, 70.

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