Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant
AbstractThe application of graphene oxide (GO) as a potential vaccine adjuvant has recently attracted considerable attention. However, appropriate surface functionalization of GO is crucial to improve its biocompatibility and enhance its adjuvant activity. In this study, we developed a simple method to prepare chitosan (CS)-functionalized GO (GO-CS) and further investigated its potential as a nanoadjuvant. Compared with GO, GO-CS possessed considerably smaller size, positive surface charge, and better thermal stability. The functionalization of GO with CS was effective in decreasing the non-specific protein adsorption and improving its biocompatibility. Furthermore, GO-CS significantly activated RAW264.7 cells and stimulated more cytokines for mediating cellular immune response, which was mainly due to the synergistic immunostimulatory effect of both GO and CS. GO-CS exhibits strong potential as a safe nanoadjuvant for vaccines and immunotherapy. View Full-Text
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Yan, T.; Zhang, H.; Huang, D.; Feng, S.; Fujita, M.; Gao, X.-D. Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant. Nanomaterials 2017, 7, 59.
Yan T, Zhang H, Huang D, Feng S, Fujita M, Gao X-D. Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant. Nanomaterials. 2017; 7(3):59.Chicago/Turabian Style
Yan, Ting; Zhang, Huijie; Huang, Dandi; Feng, Shini; Fujita, Morihisa; Gao, Xiao-Dong. 2017. "Chitosan-Functionalized Graphene Oxide as a Potential Immunoadjuvant." Nanomaterials 7, no. 3: 59.