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Nanomaterials 2017, 7(12), 434; doi:10.3390/nano7120434

Development of Octyl Methoxy Cinnamates (OMC)/Silicon Dioxide (SiO2) Nanoparticles by Sol-Gel Emulsion Method

Department of Cosmetic Science, Providence University, Taichung 43301, Taiwan
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Received: 13 November 2017 / Revised: 26 November 2017 / Accepted: 27 November 2017 / Published: 7 December 2017
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Abstract

Although octyl methoxy cinnamates (OMC) is the most used Ultraviolet B (UVB) filter in sunscreen, it has poor light stability in emulsion system. In this study, OMC/SiO2 nanoparticles were prepared via sol-gel emulsion method. Tetraethoxy silane (TEOS) was used as the silica source to encapsulate OMC. Modification of experimental parameters such as stirring speed of condensation reaction and emulsion condition, pH value of acid-catalyzed, surfactant and different percentage of TEOS and OMC, adding of OMC and surfactant to different phase may affect the particle size, and yield and entrapment efficiency in preparation process of OMC/SiO2 nanoparticles. Concluding all the parameter, we found that when condensation reaction and emulsion conditions are at 1000 rpm, pH 1.5, Span 80/Tween 20, TEOS/OMC ratios 1:1, OMC and surfactants added in oil phase, resulting in smaller particle sizes 476.5 nm, higher yield 95.8%, and higher entrapment efficiency 61.09%. Fourier transform infrared (FTIR) analysis demonstrated that OMC/SiO2 nanoparticles were successfully prepared. In vitro release profile supposed that OMC/SiO2 nanoparticles can delay OMC releasing and had 60.83% decreasing of cumulative amount. Therefore, the OMC/SiO2 nanoparticles have the potential to develop as new sunscreen materials in the use for cosmetics field in the future. View Full-Text
Keywords: octyl methoxy cinnamates (OMC); OMC/SiO2 nanoparticles; sol-gel emulsion method; tetraethoxy silane (TEOS); in vitro release profile octyl methoxy cinnamates (OMC); OMC/SiO2 nanoparticles; sol-gel emulsion method; tetraethoxy silane (TEOS); in vitro release profile
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wu, P.-S.; Lee, Y.-C.; Kuo, Y.-C.; Lin, C.-C. Development of Octyl Methoxy Cinnamates (OMC)/Silicon Dioxide (SiO2) Nanoparticles by Sol-Gel Emulsion Method. Nanomaterials 2017, 7, 434.

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