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Nanomaterials 2016, 6(9), 167; doi:10.3390/nano6090167

Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA

1
Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences and the Center of Nanoscience and Nanotechnology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
2
Department of Chemistry, University of Milan, via Golgi 19, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Leonid Gurevich
Received: 29 July 2016 / Revised: 24 August 2016 / Accepted: 26 August 2016 / Published: 8 September 2016
(This article belongs to the Special Issue DNA-Based Nanotechnology)
View Full-Text   |   Download PDF [1679 KB, uploaded 8 September 2016]   |  

Abstract

Here we described the preparation and characterization by atomic force microscopy of dumbbell-shaped conjugates between 450 bp double-stranded DNA polymer, poly(dG)-poly(dC), and 5 nm gold nanoparticles (GNPs). We have demonstrated that the size of the nanoparticles in the conjugates can be increased in a controlled fashion. Application of the conjugates for measuring the electrical conductivity of DNA is discussed. View Full-Text
Keywords: atomic force microscopy; gold nanoparticles; DNA nanotechnology; poly(dG)-poly(dC) atomic force microscopy; gold nanoparticles; DNA nanotechnology; poly(dG)-poly(dC)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Eidelshtein, G.; Fattal, M.; Avishai, G.; Kempinski, B.; Giannini, C.; Kotlyar, A. Preparation, Characterization and Manipulation of Conjugates between Gold Nanoparticles and DNA. Nanomaterials 2016, 6, 167.

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