Next Article in Journal
Application of L-Aspartic Acid-Capped ZnS:Mn Colloidal Nanocrystals as a Photosensor for the Detection of Copper (II) Ions in Aqueous Solution
Next Article in Special Issue
Noise Removal with Maintained Spatial Resolution in Raman Images of Cells Exposed to Submicron Polystyrene Particles
Previous Article in Journal
The Influence of Fluorination on Nano-Scale Phase Separation and Photovoltaic Performance of Small Molecular/PC71BM Blends
Previous Article in Special Issue
Multifunctional Inorganic Nanoparticles: Recent Progress in Thermal Therapy and Imaging
Article Menu

Export Article

Open AccessReview
Nanomaterials 2016, 6(5), 81;

Dye-Doped Fluorescent Silica Nanoparticles for Live Cell and In Vivo Bioimaging

Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology and Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University, Changsha 410082, China
Authors to whom correspondence should be addressed.
Academic Editor: Yurii Gun'ko
Received: 14 February 2016 / Revised: 20 April 2016 / Accepted: 20 April 2016 / Published: 27 April 2016
(This article belongs to the Special Issue Nanoparticles in Bioimaging)
View Full-Text   |   Download PDF [3701 KB, uploaded 27 April 2016]   |  


The need for novel design strategies for fluorescent nanomaterials to improve our understanding of biological activities at the molecular level is increasing rapidly. Dye-doped fluorescent silica nanoparticles (SiNPs) emerge with great potential for developing fluorescence imaging techniques as a novel and ideal platform for the monitoring of living cells and the whole body. Organic dye-containing fluorescent SiNPs exhibit many advantages: they have excellent biocompatibility, are non-toxic, highly hydrophilic, optically transparent, size-tunable and easily modified with various biomolecules. The outer silica shell matrix protects fluorophores from outside chemical reaction factors and provides a hydrophilic shell for the insoluble nanoparticles, which enhances the photo-stability and biocompatibility of the organic fluorescent dyes. Here, we give a summary of the synthesis, characteristics and applications of fluorescent SiNPs for non-invasive fluorescence bioimaging in live cells and in vivo. Additionally, the challenges and perspectives of SiNPs are also discussed. We prospect that the further development of these nanoparticles will lead to an exciting breakthrough in the understanding of biological processes. View Full-Text
Keywords: silica nanoparticle; organic fluorescent dye; bioimaging; in vivo silica nanoparticle; organic fluorescent dye; bioimaging; in vivo

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Zhang, W.-H.; Hu, X.-X.; Zhang, X.-B. Dye-Doped Fluorescent Silica Nanoparticles for Live Cell and In Vivo Bioimaging. Nanomaterials 2016, 6, 81.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top