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Nanomaterials 2016, 6(3), 48; doi:10.3390/nano6030048

Colloidal Gold-Mediated Delivery of Bleomycin for Improved Outcome in Chemotherapy

1
Department of Physics, Ryerson University, Toronto, ON M5B 2K3, Canada
2
CytoViva Inc., 570 Devall Drive, Auburn, AL 36832, USA
3
Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, ON M5B 1W8, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Marek Osinski
Received: 4 January 2016 / Revised: 23 February 2016 / Accepted: 26 February 2016 / Published: 10 March 2016
(This article belongs to the Special Issue Current Trends in Colloidal Nanocrystals)
View Full-Text   |   Download PDF [3611 KB, uploaded 10 March 2016]   |  

Abstract

Nanoparticles (NPs) can be used to overcome the side effects of poor distribution of anticancer drugs. Among other NPs, colloidal gold nanoparticles (GNPs) offer the possibility of transporting major quantities of drugs due to their large surface-to-volume ratio. This is while confining these anticancer drugs as closely as possible to their biological targets through passive and active targeting, thus ensuring limited harmful systemic distribution. In this study, we chose to use bleomycin (BLM) as the anticancer drug due to its limited therapeutic efficiency (harmful side effects). BLM was conjugated onto GNPs through a thiol bond. The effectiveness of the chemotherapeutic drug, BLM, is observed by visualizing DNA double strand breaks and by calculating the survival fraction. The action of the drug (where the drug takes effect) is known to be in the nucleus, and our experiments have shown that some of the GNPs carrying BLM were present in the nucleus. The use of GNPs to deliver BLM increased the delivery and therapeutic efficacy of the drug. Having a better control over delivery of anticancer drugs using GNPs will establish a more successful NP-based platform for a combined therapeutic approach. This is due to the fact that GNPs can also be used as radiation dose enhancers in cancer research. View Full-Text
Keywords: colloidal gold nanoparticles; anticancer drug; bleomycin; DNA double strand breaks; nanomedicine; drug delivery colloidal gold nanoparticles; anticancer drug; bleomycin; DNA double strand breaks; nanomedicine; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yang, C.; Uertz, J.; Chithrani, D.B. Colloidal Gold-Mediated Delivery of Bleomycin for Improved Outcome in Chemotherapy. Nanomaterials 2016, 6, 48.

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