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Nanomaterials 2016, 6(1), 1; doi:10.3390/nano6010001

Synthesis and Application of Amine Functionalized Iron Oxide Nanoparticles on Menaquinone-7 Fermentation: A Step towards Process Intensification

1
Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 74615, Iran
2
Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz 71348, Iran
3
School of Engineering, Faculty of Science and Engineering, The University of Waikato, Hamilton 3240, New Zealand
*
Author to whom correspondence should be addressed.
Academic Editor: Yurii Gun'ko
Received: 17 November 2015 / Revised: 19 December 2015 / Accepted: 21 December 2015 / Published: 25 December 2015
View Full-Text   |   Download PDF [4446 KB, uploaded 25 December 2015]   |  

Abstract

Industrial production of menaquione-7 by Bacillus subtilis natto is associated with major drawbacks. To address the current challenges in menaquione-7 fermentation, studying the effect of magnetic nanoparticles on the bacterial cells can open up a new domain for intensified menqainone-7 process. This article introduces the new concept of production and application of l-lysine coated iron oxide nanoparticles (l-Lys@IONs) as a novel tool for menaquinone-7 biosynthesis. l-Lys@IONs with the average size of 7 nm were successfully fabricated and were examined in a fermentation process of l-Lys@IONs decorated Bacillus subtilis natto. Based on the results, higher menaquinone-7 specific yield was observed for l-Lys@IONs decorated bacterial cells as compared to untreated bacteria. In addition, more than 92% removal efficacy was achieved by using integrated magnetic separation process. The present study demonstrates that l-Lys@IONs can be successfully applied during a fermentation of menaquinone-7 without any negative consequences on the culture conditions. This study provides a novel biotechnological application for IONs and their future role in bioprocess intensification. View Full-Text
Keywords: immobilization; downstream processing; magnetic nanoparticles; MK-7; bioseparations; fermentation immobilization; downstream processing; magnetic nanoparticles; MK-7; bioseparations; fermentation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ebrahiminezhad, A.; Varma, V.; Yang, S.; Ghasemi, Y.; Berenjian, A. Synthesis and Application of Amine Functionalized Iron Oxide Nanoparticles on Menaquinone-7 Fermentation: A Step towards Process Intensification. Nanomaterials 2016, 6, 1.

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