T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis
AbstractIron oxide nanoparticles have long been studied as a T2 contrast agent in MRI due to their superparamagnetic behavior. T1-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and/or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles (fdIONP), in a single step, as a viable tool for cell labeling and T1-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice. View Full-Text
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Bhavesh, R.; Lechuga-Vieco, A.V.; Ruiz-Cabello, J.; Herranz, F. T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis. Nanomaterials 2015, 5, 1880-1890.
Bhavesh R, Lechuga-Vieco AV, Ruiz-Cabello J, Herranz F. T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis. Nanomaterials. 2015; 5(4):1880-1890.Chicago/Turabian Style
Bhavesh, Riju; Lechuga-Vieco, Ana V.; Ruiz-Cabello, Jesús; Herranz, Fernando. 2015. "T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis." Nanomaterials 5, no. 4: 1880-1890.